Vicore Pharma Ab

Ge Healthcare Bio-sciences Ab

Biotage Ab

Mathias Alterman

Anders Rudolf Hallberg

Andreas Axen

Xiongyu Wu

Nils Norrman

Gunnar Glad

Tobias Soderman

Enrique Napoleon Carredano

Jinyu Zou

Mats Larhed

Dag Lindstrom

Ulrika Meyer

Nils-Fredrik Kaiser

Murugaiah Andappan Murugaiah Subbaiah

Yiqian Wan

Hallberg Anders

Andreas Ge Healthcare Bio-Sciences Ab Axen

Anna Ge Healthcare Bio-Sciences Ab Grönberg

Enrique Ge Healthcare Bio-Sciences Ab Carredano

Jinyu Ge Healthcare Bio-Sciences Ab Zou

A Department Of Medicinal Chemistry Hallberg

Xiongyu Department Of Medicinal Chemistry Wu

Anders Dept Of Medicinal Chemistry Hallberg

There is provided a compound of formula I, wherein R, R, X, Y, Y, Y, Y, Z, Z, Rand Rhave meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.

Bicyclic angiotensin II agonists

There is provided compounds of formula (I), wherein X, X, X, Y, Y, Y, Y, Y, Z, Z, Rand Rhave meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.

Tricyclic compounds useful as angiotensin II agonists

There is provided compounds of formula I, wherein A, X, X, X, X, Y, Y, Y, Y, Z, Z, Rand Rhave meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.

Tricyclic angiotensin II agonists

There is provided compounds of formula I, wherein the dotted line, X, X, X, A, Y, Y, Y, Y, Z, Z, Rand Rhave meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful as selective agonists of the AT2 receptor, and thus, in particular, in the treatment of inter alia gastrointestinal conditions, such as dyspepsia, IBS and MOF, and cardiovascular disorders.

The present invention relates to magnetic beads suitable for, for example, isolation of proteins, cells, and viruses and also for diagnostic applications and cell cultivation. The magnetic beads are composite beads with an inner core of metal particles, which are coated with an inert synthetic polymer and these are then enclosed in a hydrophilic porous polymer, preferably agarose. This provides porous biocompatible beads without metal leakage. The beads may be used for cell cultivation or for chromatography. When the beads are used for chromatography the agarose layer is preferably provided with ligands having affinity for selected biomolecules.

Magnetic beads comprising an outer coating of hydrophilic porous polymer and method of making thereof

The present invention relates to a chromatographic adsorbent for selectively adsorbing IgG, comprising the following formula and its corresponding enol-form, wherein X represents O, S, or NH; Rrepresents H, Calkyl, Calkoxy, Calkoxy-Calkyl, Ar, &#x2014;C(O)NHR, &#x2014;C(O)&#x2014;Ror halo; Rrepresents H, Calkyl or halo; Rrepresents H, Calkyl, Calkoxy, Calkoxy-Calkyl or Ar; n represents 0, 1, 2 or 3; Y represents a carrier. The present invention also relates to a method of producing said adsorbent as well as use thereof for separating substances by affinity chromatography.

[1, 2, 4] Triazolo [1, 5-A] pyrimidine derivatives as chromatographic adsorbent for the selective adsorption of IGG

The present invention is drawn to a method of performing a one-pot organic reactions including carbon monoxide as reactant, without the use of an external CO gas source, wherein a reaction mixture containing a solid or liquid CO releasing compound, a non-metal substrate and a metal catalyst is exposed to an energy source to release carbon monoxide from the CO releasing compound and wherein carbon atoms of the released carbon monoxide form a bond with the non-metal substrate compound. The present invention is further drawn to a method of preparing chemical libraries and a kit for organic reactions.

Organic reactions with CO generating materials

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Stockholm, Sweden

Mathias Alterman