Other

Bavarian Nordic A/s

University Of Zürich

Mathias Ackermann

Mark Suter

Cornel Fraefel

Paul Chaplin

Xandra O Breakefield

E Antonio Chiocca

Gosse Jan Adema

Sabine Vollstedt

Yoshinaga Saeki

Christiane Dresch

Bruna De Andrade Pereira

Hans Peter Hefti

Ruth Hefti, Legal Representative

Marco Franchini

Ken Shortman

Kurt Tobler

The invention relates to transgene expression constructs&#x2014;particularly self inactivating lentiviral vectors&#x2014;comprising a dendritic cell specific promoter controlling the expression of autoantigen proteins, namely myelin basic protein, proteolipid protein and myelin oligodendrocyte glycoprotein, for use in the therapy of multiple sclerosis.

APC-mediated tolerance induction for therapy of multiple sclerosis

The invention concerns the use of a virus to increase the number of dendritic cells or their precursor cells in an immunocompromised animal, including a human. The virus is preferably a Modified Vaccinia Virus Ankara which is capable of infecting the cells of a neonatal or prenatal animal, including a human, but not capable of being replicated to infectious progeny virus in the neonatal or prenatal animal, including a human.

Modified vaccinia virus ankara for the vaccination of neonates

The present invention relates to an enhanced and simplified herpes virus amplicon packaging system. The packaging system comprises a herpes virus amplicon vector and a packaging vector. In one embodiment, the packaging vector comprises a bacterial artificial chromosome (BAC) containing the HSV-1 genome. The packaging vector contains an intact pac site but is otherwise rendered packaging defective. The packaging vector can be rendered packaging defective by inserting nucleotides into the pac site, or by otherwise interfering with the capsid's ability to close, for example, by increasing the size of the DNA fragment upon which the herpes virus genome is cloned. This system can be used to package a wide range of nucleotide sequences (e.g., a therapeutic or antigenic gene) into an empty herpes virus particle taking advantage of the large transgene capacity of herpes viruses. This system can also be used as a vaccine to induce protective immunity against HSV-1, or other complex pathogens.

Enhanced packaging of herpes virus amplicons and generation of recombinant virus vectors

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Basserdorf, Switzerland

Mathias Ackermann