The Charles Stark Draper Laboratory, Inc.

Children's Medical Center Corporation

Memsic, Inc.

Mathew Varghese

Jason Oliver Fiering

Mark Joseph Mescher

Donald Elliot Ingber

Marc Steven Weinberg

Jonathan Jay Bernstein

David J Carter

Amy Elizabeth Duwel

Gregory A Kirkos

Tommy W Lee

Chong Wing Yung

Fran J Rogomentich

Jeffrey T Borenstein

Yongyao Cai

Alexander Dribinsky

Thomas F Marinis

Douglas W White

Joseph W Soucy

Gregory P Pucci

Bernard M Antkowiak

Gary J O'Brien

Joung-Mo Kang

Luke Hohreiter

Nan Xia

Fran Rogomentich

Thomas Marinis

A microfluidic device for separating target components from a source fluid includes one or more source channels connected to one or more collection channels by one or more transfer channels. The target components of the source fluid can be magnetic or bound to magnetic particles using a know binding agent. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid that is stagnant until a predefined volume of source fluid is processed or a predefined volume of target components accumulate in the collection channel, at which point collection fluid can be pumped into the collection channel to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis.

Microfluidic device and uses thereof

A method and apparatus for continuously separating or concentrating particles that includes flowing two fluids in laminar flow through a magnetic field gradient which causes target particles to migrate to a waste fluid stream, and collecting each fluid stream after being flowed through the magnetic field gradient.

Method and apparatus for separating particles, cells, molecules and particulates

Presented herein are systems, methods and devices relating to miniature actuatable platform systems. According to one embodiment, the systems, methods, and devices relate to controllably actuated miniature platform assemblies including a miniature mirror.

Systems, methods and devices for actuating a moveable miniature platform

A system, device, and method for minimizing x-axis and/or y-axis offset shift due to internally produced as well as externally produced on chip temperature imbalances. At least one temperature gradient canceling device is disposed on a substrate including a temperature gradient sensitive device having at least one pair of sensors. Voltage signals generated by the temperature gradient canceling devices can be combined with voltage signals generated by each of the pair of sensors to account for the offset.

Temperature-gradient cancelation technique and device

The invention generally relates to combining a plurality of flow streams. In various embodiments, a first channel transports a first laminar fluid flow, a second channel transports a second laminar fluid flow, and the first and second channels enter a merging region at an acute angle to one another along separate substantially parallel planes.

Devices for producing a continuously flowing concentration gradient in laminar flow

A resonator system wherein a plurality of resonators each including piezoelectric material are suspended relative to a substrate. An edge of each resonator is mechanically coupled to an edge of another resonator and the plurality of resonators expand and contract reaching resonance in response to an applied electric field.

Resonator system with a plurality of individual mechanically coupled resonators and method of making same

A suspension of a chip-scale device is accomplished using a suspension frame and at least one first tether. The chip-scale suspension frame defines a first plane and an opening through the suspension frame. At least one first tether crosses the opening at a first angle relative to the first plane and can be used to position the chip-scale device at least partially within the opening.

Apparatus and system for suspending a chip-scale device and related methods

A longitudinal mode resonator that includes a substrate and a bar that is suspended relative to the substrate. The bar is suspended such that it is free to expand and contract longitudinally in response to the application of an electric field across its thickness. The expansion and contraction of the bar achieves resonance in response to the field having a frequency substantially equal to the fundamental frequency of the bar.

MEMS piezoelectric longitudinal mode resonator

Growing community of inventors

Arlington, MA, United States of America

Mathew Varghese