Valtion Teknillinen Tutkimuskeskus

Zora Biosciences Oy

Bg Medicine, Inc.

Matej Oresic

Noubar Boghos Afeyan

Reijo Laaksonen

Aram S Adourian

Jan Van Der Greef

Eric K Neumann

Elwin Robbert Verheij

Terho Lehtimäki

Erno Lindfors

Hannu Päivä

Gopalacharyulu Peddinti

Frederick E Regnier

Method/system for visualizing biological information. The system receives a user query relating to biological information and determines which database contains related biological information. A database query is sent to the database and the result indicates biological/chemical entities and relations. A network is created based on the result; biological/chemical entities are mapped to network nodes and relations to network connections. A distance matrix indicates a multi-dimensional distance for several pairs of network nodes. A dimensionality reduction function is adjusted based on a research context, to bias the search toward a relevant focus. The number of dimensions in the distance matrix is lowered by the dimensionality reduction function. Neighbors of a selected node are searched (-) based on the distance matrix to elucidate a biological role of the selected node. A re-created network is visualized (-) based on the adjusted dimensionality reduction function.

Visualization technique for biological information

The present invention provides methods and systems for developing profiles of a biological system based on the discernment of similarities, differences, and/or correlations between biomolecular components of a plurality of biological samples. Preferably, the method comprises utilizing hierarchical multivariate analysis of spectrometric data at one or more levels of correlation.

Method and system for profiling biological systems

This invention provides a diagnostic method for determining statin induced myopathy. The method is especially applicable for determining warnings, early signs and also symptomatic myopathy. The method includes collecting a lipidomic profile from a biological sample such as blood or serum and comparing the obtained lipidomic profile to reference lipidomic markers. The reference lipidomic markers have been established by combining a pro-inflammatory muscle tissue gene expression profile with a lipidomic profile associated with high dosage statin treatment. This invention also relates to a kit for performing a method for determining statin induced myopathy.

Diagnostic method for myopathy

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Espoo, Finland

Matej Oresic