Nihon Nohyaku Co., Ltd.

Matazaemon Uchida

Kunikazu Hiraga

Masashi Nagamine

Keisuke Nakayama

Atsushi Sakai

Akira Seo

Hideo Kanno

Kenichi Ikeda

Yukio Miyagi

Nobu Hasegawa

Shuhei Kubota

Yukimi Munechika

Tetsuto Ohmi

Shigeo Konaka

Akira Nishimura

Kuniaki Taninaka

Masakazu Shibayama

Harutaka Kimura

Shuhei Kabota

Isao Nishino

The ketenedithioacetal derivatives of formula (I) have a potent hypolipidemic and anti-arteriosclerotic effect and are useful for prophylaxis and treatment of arteriosclerosis or hyperlipidemia.

Ketendithioacetal derivatives and pharmaceutical compositions containing

1,3,5-trithiane derivatives represented by the formula (I) ##STR1## wherein the substituents are defined herein, are disclosed. The trithiane derivatives and their compositions are useful as anti-arteriosclerotic or anti-hyperlipemic agents.

1,3,5-trithiane derivatives and pharmaceutical compositions thereof

Novel dithiolane derivatives of formula: ##STR1## wherein X is, a C.sub.2 -C.sub.7 alkylcarbonyl group, benzoyl group, benzoyl group substituted with 1-3 groups selected from halogen, C.sub.1 -C.sub.4 alkyl, and C.sub.1 -C.sub.4 alkoxy; Y represents C.sub.2 -C.sub.7 alkylcarbonyl group, C.sub.2 -C.sub.7 alkoxycarbonyl group or cyano group; and R represents di (C.sub.1 -C.sub.4 alkylamino) group, morpholino group or piperidino group, are produced by reacting glyoxal sodium bisulfite adduct with amine compounds in the presence of acids and then with dithiolates. The dithiolane derivatives can activate liver functions and are effective for treatment and prophylaxis of hepatitis and other hepatic disorders.

Dithiolane derivatives

A curing agent for fat necrosis which contains a dithia derivative represented by the general formula ##STR1## wherein R and R.sup.1 may be either the same or different and denote a lower alkyl group; n denotes an integer of 0, 1 or 2; and A denotes --CH.sub.2 --, ##STR2## M being H or a salt-forming rest, --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, or ##STR3## and a method for curing said disease using the said curing agent.

Curing agent for fat necrosis and method for curing said disease

A cyclohexanedione derivative represented by the general formula (I); ##STR1## wherein R.sup.1, R.sup.4 and R.sup.7 represent independently hydrogen atom or C.sub.1 -C.sub.8 alkyl group, R.sup.2 represents hydrogen atom; C.sub.1 -C.sub.8 alkyl group; C.sub.2 -C.sub.6 alkenyl group; C.sub.3 -C.sub.8 cycloalkyl group; C.sub.2 -C.sub.7 alkoxycarbonyl group; C.sub.1 -C.sub.6 alkylthio C.sub.1 -C.sub.6 alkyl group; a phenyl group; a phenyl group substituted with 1 to 3 groups selected from the group consisting of halogen atom, C.sub.1 -C.sub.6 alkyl group, C.sub.1 -C.sub.6 haloalkyl group, C.sub.1 -C.sub.6 alkoxy group, C.sub.1 -C.sub.6 alkylthio group, C.sub.3 -C.sub.8 cycloalkoxy group, a benzyloxy group and a benzyloxy group substituted with C.sub.1 -C.sub.6 alkoxy group; naphthyl group or a heterocyclic group, R.sup.3 represents hydrogen atom, C.sub.1 -C.sub.8 alkyl group or C.sub.2 -C.sub.7 alkoxycarbonyl group, and R.sup.5 and R.sup.6, which may be the same or different, represent hydrogen atom, C.sub.1 -C.sub.6 alkyl group, C.sub.2 -C.sub.6 alkenyl group, C.sub.2 -C.sub.7 alkylcarbonyl group or C.sub.2 -C.sub.7 haloalkylcarbonyl group or its pharmaceutically acceptable salts; a pharmaceutical composition containing the same that treats hepatic disorders; and a process for producing the same.

Cyclohexanedione derivative for hepatic disorders and a process for

This invention relates to a malonic acid derivative represented by the general formula (I) ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, represents hydrogen atom; C.sub.1 -C.sub.12 alkyl group; C.sub.1 -C.sub.8 alkyl group substituted with C.sub.1 -C.sub.5 alkoxy group, a tetrahydrofuryl group, a phenyl group or a phenyl group substituted with 1 to 3 groups selected from the group consisting of halogen atoms, C.sub.1 -C.sub.5 alkyl groups and C.sub.1 -C.sub.5 alkoxy groups; or C.sub.2 -C.sub.6 alkenyl group; R.sup.3 and R.sup.4, which may be the same or different, represent hydrogen atom, C.sub.1 -C.sub.6 alkyl group, C.sub.2 -C.sub.6 alkenyl group, C.sub.2 -C.sub.8 alkoxyalkyl group, benzoyl group, C.sub.2 -C.sub.8 alkylcarbonyl group, C.sub.2 -C.sub.8 alkoxycarbonyl group, C.sub.1 -C.sub.4 alkylsulfonyl group or aralkyl group including benzyl group, and R.sup.5, R.sup.6 and R.sup.7, which may be the same or different, represent hydrogen atom or C.sub.1 -C.sub.4 alkyl group, and its pharmaceutically acceptable salts, a process for producing the same and a pharmaceutical composition containing the same.

Malonic acid derivatives

An anti-arteriosclerotic or anti-hyperlipemic 1,3,5-trithiane derivative according to the formula (I): ##STR1## a pharmaceutical composition containing the same, and a process for producing the same.

1,3,5-trithian derivatives and pharmaceutical compositions

A novel ketene S,S-acetal derivative which is useful as an antimycotic agent and an agricultural chemical of fungicidal, plant growth regulating or insecticidal properties represented by the general formula (I): ##STR1## wherein R represents a hydrogen atom; an alkyl group having 1 to 8 carbon atoms; a cycloalkyl group having 3 to 6 carbon atoms; a methylene group; a lower alkenyl group; a lower alkyl group substituted by a halogen atom, a cyano group, a lower alkoxyl group, a lower alkylthio group; a carbamoyl group, an acyl group, or an alkenoyloxy group; a phenyl group represented by ##STR2## (in which R.sub.1 represents a hydrogen atom, a halogen atom, a straight or branched chain lower alkyl group, a lower alkoxyl group which may be substituted by one or more halogen atoms, a phenoxy group or a methylenedioxy group, and m represents an integer of 1 to 3); a benzyl group; a methylenedioxybenzyl group; a phenoxyalkyl group; a phenoxyalkyl group substituted by a halogen atom; a naphthyl group; or a substituted or unsubstituted pyridyl group.

Antimycotic agent and fungicidal agent

A novel ketene S,S-acetal derivative which is useful as an antimycotic agent and an agricultural chemical of fungicidal, plant growth regulating or insecticidal properties represented by the general formula (I): ##STR1## wherein R represents a hydrogen atom; an alkyl group having 1 to 8 carbon atoms; a cycloalkyl group having 3 to 6 carbon atoms; a methylene group; a lower alkenyl group; a lower alkyl group substituted by a halogen atom, a cyano group, a lower alkoxy group, a lower alkylthio group; a carbamoyl group, an acyl group, or an alkenoyloxy group; a phenyl group represented by ##STR2## (in which R.sub.1 represents a hydrogen atom, a halogen atom, a straight or branched chain lower alkyl group, a lower alkoxyl group which may be substituted by one or more halogen atoms, a phenoxy group or a methylenedioxy group, and m represents an integer of 1 to 3); a benzyl group; a methylenedioxybenzyl group; a phenoxyalkyl group; a phenoxyalkyl group substituted by a halogen atom; a naphthyl group; or a substituted or unsubstituted pyridyl group.

Growing community of inventors

Kawachinagano, Japan

Matazaemon Uchida