Takeda Chemical Industries, Inc.

Takeda Pharmaceutical Company Limited

Masuo Yamaoka

Tomohiro Kaku

Akihiro Tasaka

Masami Kusaka

Akio Ojida

Tetsuya Aono

Fumio Itoh

Shohei Hashiguchi

Shogo Marui

Masafumi Nakao

Yoshi Nara

Noritaka Kuroda

A composition containing a compound of the formula: wherein A is a nitrogen-containing heterocyclic group which may be substituted, Ris a hydrogen atom, hydrocarbon group which may be substituted, or monocyclic aromatic heterocyclic group which may be substituted, Ris a hydrogen atom or a lower alkyl group which may be substituted, R, R, R, R, R, Rand Rare independently a hydrogen atom, a hydrocarbon group which may be substituted, a hydroxy group which may be substituted, a thiol group which may be substituted, an amino group which may be substituted, an acyl group or a halogen atom, a salt thereof or a prodrug thereof has steroid C-lyase inhibitory activity, and are useful for preventing and treating a mammal suffering from, for example, primary cancer of malignant tumor, its metastasis and recurrence thereof.

Naphthalene derivatives, their production and use

The present invention provides a pharmaceutical composition having a steroid C-lyase inhibitory activity, which is useful as a prophylactic or therapeutic agent of prostatism, tumor such as breast cancer and the like, more particularly, a steroid C-lyase inhibitor containing a compound represented by the formula: wherein Ais an aromatic hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, one of Aand Ais a hydrogen atom, a halogen atom, a Caliphatic hydrocarbon group optionally having substituents or an optionally esterified carboxyl group, the other of Aand Ais an aromatic hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, and at least one of A, Aand Ais a 3-pyridyl group optionally having substituents, or a salt thereof or a prodrug thereof.

Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof

Imidazol-4-ylmethanols and their uses for preventing and treating primary tumors, metastasis and recurrence of tumors, various symptoms accompanying tumors, prostatic hypertrophy, virilism, hirsutism, male pattern alopecia, precocious puberty, endometriosis, uterine myoma, mastopathy and polycystic ovary syndrome are disclosed.

Imidazol-4-ylmehanols and their use as inhibitors of steroid C17-20 lyase

Fused ring compounds, process for producing the same and use thereof

Heterocyclic compounds, their production and use

Growing community of inventors

Kobe, Japan

Masuo Yamaoka