Mochida Pharmaceutical Co., Ltd.

Yamaguchi University

Osaka University

Otsuka Pharmaceutical Company, Limited

Mochida Pharmaceutical., Ltd.

Masunori Matsuzaki

Yasushi Saito

Yuji Matsuzawa

Hideki Origasa

Mitsuhiro Yokoyama

Shinichi Oikawa

Yuichi Ishikawa

Hiroshige Itakura

Toru Kita

Toshiie Sakata

Koichi Yoshimura

Hiroki Aoki

Kunio Shirato

Kazuyuki Shimada

Noriaki Nakaya

Akira Kitabatake

Hitoshi Hishida

Jun Sasaki

Masahiko Ohta

Shunichi Kuroda

Hiromori Tsutsumi

Chie Teruyama

Masafumi Yano

Takeshi Yamamoto

Disclosed is a composition which is useful for preventing the occurrence of a cardiovascular event, particularly a composition which is expected to show a prophylactic effect on a cardiovascular event occurring in a hypercholesterolemia patient despite providing the patient with a treatment with HMG-CoA RI or a cardiovascular event occurring in a multiple risk patient.

Composition for preventing the occurrence of cardiovascular event in multiple risk patient

A medical composition for reducing the rate of new-onset diabetes caused by administration of a statin or for inhibiting an increase in blood glucose level by administration of a statin, the composition containing at least one ingredient selected from the group consisting of icosapentaenoic acid and pharmaceutically acceptable salts or esters thereof as an inactive ingredient.

Composition for reducing new-onset diabetes

By using a composition for preventing onset and/or recurrence of stroke which contains ethyl icosapentate as its effective component, onset and/or recurrence of stroke is prevented, or in particular, the onset and/or recurrence of stroke in a hyperlipidemia patient who has been treated with HMG-CoA RI, or in particular the recurrence of stroke in a patient who is beyond six months after the onset of stroke, is prevented.

Composition and/or method for preventing recurrence of stroke

Provided are composition and/or methods useful in preventing onset and/or recurrence of cardiovascular events, especially in patients who have escaped the unstable period after cardiovascular angioplasty or in hyperlipidemia patients who have been treated with HMG-CoA RI.

Composition and/or method for preventing onset and/or recurrence of cardiovascular events

It is a main object of the present invention to provide a drug delivery system in which drugs can be changed or which can be recharged with drugs, which continuously delivers drugs at effective concentrations to local lesional sites in a body and allows the use of drugs for which it has thus far been difficult to achieve effective local concentrations for a variety of reasons and drugs which have been difficult to use due to adverse effects on tissues that are not sites of action. The present invention provides a drug delivery system comprising an indwelling medical device on which a biocompatible material having target molecules on its surface has been coated, and target-recognizing nanocarriers (e.g., bio-nanocapsules, liposomes, liposome preparations, and nanoparticles) in which drugs are encapsulated and which have target-recognizing molecules capable of specifically binding to the target molecules.

Drug delivery system

A polypeptide exhibiting the effect of inhibiting Caleakage in a target cell, the polypeptide having the amino acid sequence of any of SEQ ID NOs: 3 to 9 or an amino acid sequence obtained through deletion, insertion, substitution, or addition of one or more amino acids in the aforementioned amino acid sequence; a polynucleotide encoding the polypeptide; and a pharmaceutical composition containing, as an active ingredient, the polypeptide or an expression product of the polynucleotide.

Polypeptide derived from the ryanodine receptor that inhibits calcium leakage

The present invention relates to a prophylactic agent or a therapeutic agent for a disorder of collagen or elastin metabolism, which comprises a substance possessing JNK inhibitory activity as an active ingredient.

Preventive and remedy for collagen or elastin metabolic disorder

Composition and method for preventing recurrence of stroke

Growing community of inventors

Yamaguchi, Japan

Masunori Matsuzaki