Shionogi Company Limited

Masuhisa Nakamura

Kunio Hayashi

Tatsuo Toyoda

Yukio Yonetani

Toshihiro Fujioka

Naofumi Hashimoto

Hiroshi Harada

Yoshihiro Matsushita

Hiroshi Itazaki

Masao Kono

Munenori Matsuura

Ken Inouye

Nobuo Yoshida

Tadashi Okabayashi

Ken'ichi Igano

A following dipeptide derivative of the following formula (I) is provided, which is capable of inhibiting the enzymatic activity of renin and thereby depressing the renin-angiotensin system and lowering the blood pressure. ##STR1## wherein: R.sup.1 is C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.10 cycloalkyl, aryl, or heterocyclic radical;

Dipeptide derivatives

A dipeptide derivative of the formula (I) is provided, which is capable of inhibiting the enzymatic activity of renin and thereby depressing the renin-angiotensin system and lowering the blood pressure, provided. ##STR1## wherein: R.sup.1 is C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.10 cycloalkyl, aryl, or heterocyclic radical;

A dipeptide derivative of formula (I) is provided, which is capable of inhibiting the enzymatic activity of renin and thereby depressing the renin-angiotensin system and lowering the blood pressure. ##STR1## wherein: R.sup.1 is C.sub.1 -C.sub.12 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.10 cycloalkyl, aryl, or heterocyclic radical;

Highly effective diuretic antihypertensives, i.e., sulfamoyl-2-benzofurancarboxylic acid derivatives which are classified as loop diuretics with less adverse side-effects and can be administered orally at a daily dosage of 0.5 mg to 200 mg or parenterally at 0.01 mg to 50 mg.

Sulfamoyl-2-benzofurancarboxylic acid derivative

Highly effective diuretic antihypertensives, i.e., 2,3-dihydrobenzofuran-5-sulfonamide derivatives which is classified to loop diuretics with less adverse side-effects and can be administered orally at a daily dosage of 0.5-200 mg or parenterally of 0.01-50 mg.

2,3-dihydrobenzofuran-5-sulfonamide derivatives useful as

Highly safe new diuretics, i.e., 1,4-benzodioxane and 1,4-benzodioxine derivatives having potent antihypertensive activity but no or little uricesuric activity, which can be administered to human orally, intravenously, or hypodermically at a respective daily dosage of 0.1-2 mg/kg, 0.005-0.1 mg/kg, or 0.02-0.4 mg/kg.

1,4-benzodioxine and 1,4-benzodioxine derivatives and production thereof

The disclosed peptide derivative of the formula:

Growing community of inventors

Takarazuka, Japan

Masuhisa Nakamura