Bracco Imaging S.p.a.

Dibra S.p.a.

Bracco International Bv

Massimo Visigalli

Luciano Lattuada

Fulvio Uggeri

Silvio Aime

Marino Brocchetta

Pier Lucio Anelli

Roberta Napolitano

Giovanni Battista Giovenzana

Alessandro Maiocchi

Valeria Boi

Pernille Rose Jensen

Magnus Karlsson

Fabio Tedoldi

Mathilde H Lerche

Alberto Fringuello Mingo

Attilio Citterio

Gabriella Leonardi

Chiara Gallotti

Evelin Vignale

Roberta Fretta

Christoph De Haen

Pierfrancesco Morosini

Simona Ghiani

Federica Buonsanti

Giovanna Lux

Ornella Gazzotti

Giuseppe Manfredi

Claudia Cabella

Luigi Miragoli

Sonia Colombo Serra

Luisa Poggi

Michele Serleti

Daniela Palano

Roberta Mazzon

Elisa Battistini

Aurelia Ferrigato

Chiara Brioschi

Loredana Sini

Gabriele Meli

Davide Belnome

Pierlucio Anelli

Marco Crosetti

Lorena Beltrami

The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

Contrast agents

The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.

The present invention relates to paramagnetic solid lipid nanoparticles (pSLNs) comprising an amphiphilic paramagnetic metal chelating moiety selected from: a diazepine derivative of Formula I and a tetraazocyclododecane derivative of Formula (II): being said chelating moiety complexed to a paramagnetic metal ion selected from the group consisting of: Gd(III), Mn(II), Cr(III), Cu(II), Fe(III), Pr(III), Nd(III), Sm(III), Tb(III), Yb(III), Dy(III), Ho(III) and Er(III), or salts thereof. The invention further relates to the process for preparation of said solid lipid nanoparticles comprising amphiphilic complexes of paramagnetic metals (pSLNs) and to the use of pSLNs as MRI contrast agents in the diagnostic field.

Paramagnetic solid lipid nanoparticles (pSLNs) containing metal amphiphilic complexes for MRI

The present invention generally relates to a composition comprising acetic anhydride, a DNP agent and a gadolinium complex and its use for the preparation of hyperpolarised imaging agent for MR diagnostic analysis.

Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis

The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue.

Process for preparing hyperpolarized substrates and method for MRI

New radical compounds, useful in the field of MRI imaging of formula (I). The radical compounds are in particular new triarylmethyl ('trityl') radicals which can be used as polarizing agents for polarizing a molecule in the DNP process. 

Triarylmethyl radicals

The present invention relates to a new class of diazepine-derivatives as chelating agents for paramagnetic metal ions, the process for their preparation, and use of such paramagnetic complexes as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis. The present invention refers to a new class of derivatives of formula (I), or a pharmaceutically acceptable salt thereof. 

Class of diazepine derivative chelating agents and complexes with paramagnetic metals thereof as MRI contrast agents

The present invention relates to a process for the preparation of iodinated anilines; in particular, it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted anilines to the corresponding 3,5-disubstituted-2,4,6-triiodoanilines, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. 

Process for the iodination of aromatic compounds

The present invention relates to a process for the preparation of iodinated phenols; in particular; it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted phenol compounds to the corresponding 3,5-disubstituted-2,4,6-triiodophenols, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves.

Process for the iodination of phenolic derivatives

Bile acid salts

Blood pool imaging contrast agents containing paramagnetic bi- and tri-valent metal ion chelates of bile acid conjugates with molecules having chelating activity are used in magnetic resonance imaging of the vascular system and particularly the coronaries.

Use of bile acid conjugates, derivatives thereof with metal complexes as blood pool agents for nuclear magnetic resonance diagnostics

A process for the preparation of the compounds of general formula (I)

Process for the preparation of bile acid derivatives

The invention relates to novel contrast media particularly useful for X-ray diagnostic investigations of human and animal body.

Biphenyl iodinated derivatives and their diagnostic use

##STR1## wherein R, R', R.sub.1, and R.sub.1 ', which are the same or different, are H, C.sub.1 -C.sub.4 alkyl, linear or branched C.sub.1 -C.sub.4 mono- or polyhydroxyalkyl; R.sub.2, R.sub.2 ', R.sub.3, and R.sub.3 ', which are the same or different, are one of the groups of formula --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH(OH) CH.sub.2 OH --CH(CH.sub.2 OH)CH(OH)CH.sub.2 OH, --CH.sub.2 (CHOH).sub.4 CH.sub.2 OH, or --CH(CH.sub.2 OH).sub.2 ; and X is one of the groups --CH(OH)--, --CH(CH.sub.2 OH)--, --C(OH) (CH.sub.2 OH)--, or --C(CH.sub.2 OH).sub.2 --, are useful as opacifying components for X-ray contrast media.

5,5'-/(1,3-propanediyl)

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Settala, Italy

Massimo Visigalli