Zach System S.p.a.

Wyeth

Zach Systems S.p.a.

Chiesi Farmaceutici S.p.a.

Zambon S.p.a.

F.i.s. Fabbrica Italiana Sintetici S.p.a.

Flamma S.p.a.

Zetacube S.r.l.

Massimo Verzini

Livius Cotarca

Giorgio Soriato

Paolo Maragni

Roberto Brescello

Johnny Foletto

Ivan Michieletto

Vincenzo Cannata

Roberto Giovanetti

Raffaella Volpicelli

Nicola Catozzi

Pietro Allegrini

Massimiliano Forcato

Alberto Guidi

Elisa Melotto

Mauro Andretto

Alfonso Melloni

Paolo Andreella

Giuseppe Barreca

Andrea Nicoli

Franco Massaccesi

Ilaria Munari

Fabio Bassan

Antonio Nardi

Daniele Urbani

Anna Smaniotto

Francesco Tasinato

Marco Demo

Marco Villa

Franco Pellacini

Mauro Napoletano

Maria Argese

Dario Braga

Maurizio Paiocchi

Francisco Marquillas Olondriz

Gabriele Morazzoni

Aldo Belli

Kadum A Ali

Angelo Restelli

Francesco Corcella

Katiuscia Arrighi

Corrado Colli

Wei He

Paolo Cremonesi

Malama K Chibwe

Shridhar G Gangolli

Carl E Longfellow

Leila Vahdati

Mario Scotti

Daniela Comi

Francesco Chiesa

Enrico Pace

Maurizio Polentarutti

Giorgio Bais

Jasper Rikkert Plaisier

Fabio Belluzzo

Alessandro Di Maria

Maurizio Benaglia

Vincenzo Frega

Filippo Chiarello

Gianmauro Orru'

Jean-Claude Kizirian

Elisenda Trepat Guixer

Mauro Maffini

Paolo Fornasari

Franco Brazzarola

Dario Università Di Bologna Braga

The present invention relates to a process for the purification of (R)-2-amino-3-phenylpropyl carbamate in perspective of the subsequent conversion in the corresponding HCl salt (SOLRIAMFETOL). The invention further relates to the process for preparing a batch of purified solriamfetol, as well as to the purified (R)-2-amino-3-phenylpropyl carbamate or its hydrochloride salt.

Process for the purification of (R)-2-amino-3-phenylpropyl carbamate

The present invention relates to a process for preparing 3-amino tetrahydropyrans and, more particularly, to an improved method for synthesizing a 2,3,5-substituted tetrahydropyran derivative, intermediate being used in the preparation of dipeptidyl peptidase-IV enzyme inhibitors (DPP-4 inhibitors).

Process for preparing aminotetrahydropyrans

The present invention relates to a process for the cyclopropanation with ethylene carbonate or ethylene sulfate of a compound of formula (II): wherein G is &#x2014;CN or &#x2014;COOR in which R is a C-Cstraight or branched alkyl X and Y are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, RO&#x2014; and RS&#x2014; wherein Ris C1-C4 straight or branched alkyl chain. 

Cyclopropanation of substituted phenylacetonitriles or phenyl acetates

A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine hydrochloride salt of formula (I) i.e. Cinacalcet hydrochloride and its intermediates of formulae (VII) and (VIII) wherein Z is chloride or another pharmaceutically acceptable anionic counterion.

Process for preparing Cinacalcet hydrochloride

A method of detecting polymorphs using X-ray produced by a synchrotron source is described. In particular, the method allows to detect particular polymorphs present in small amounts in mixtures of polymorphic compounds present in a prevailing amount. The method offers a powerful resolution of mixtures of polymorph and finds application particularly in the pharmaceutical field.

Method of detecting polymorphs using synchrotron radiation

The present invention relates to a chiral oxamide of formula (I) useful as an intermediate in the preparation of dorzolamide, and to the preparation thereof. The invention also relates to the preparation of dorzolamide, to the hydrochloride salt thereof, and to the active ingredient contained in a drug useful in the treatment of glaucoma, by means of the intermediate of formula (I). 

Process for preparing enantiomerically enriched oxamides

The present invention relates to a process for preparing gabapentin and, more particularly, it relates to a process for the direct extraction of gabapentin from an aqueous solution derived from the Hofmann rearrangement of 1,1-cyclohexanediacetic acid monoamide.

Process for preparing gabapentin

The present invention relates to a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof:   wherein R is as defined above and G is &#x2014;CN or &#x2014;COORwherein Ris a C-Cstraight or branched alkyl chain.

Process for the preparation of derivatives of 1-(2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid

The present invention relates to a process for preparing a ketosulfone derivative and, more particularly, to an improved method for synthesizing 1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]ethanone by means of Pd-catalized alpha arylation process of a heteroaromatic ketone derivative.

Process for preparing a ketosulfone derivative

The present invention relates to a process for preparing Nebivolol and, more in particular, to a fractional distillation method of a mixture of stereoisomers of formula intermediates useful in the preparation of nebivolol.

Process for preparing nebivolol

The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.

Process for preparing Bosentan monohydrate and it's intermediates

The present invention relates to a stereoselective reduction procedure to obtain, by means of catalytic asymmetric hydrogenation by hydrogen transfer, a compound of formula (I) in which X is S or SOand Ris hydrogen or an SONHgroup, from the corresponding ketone precursor, said compound of formula (I) being useful as an intermediate in the preparation of dorzolamide or of the hydrochloride salt thereof. 

Asymmetric reduction process

The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved method of debenzylation of a compound of formula (II) useful for preparing nebivolol endowed with high purity. 

Process for preparing Nebivolol

The present invention relates to a process for the preparation of olopatadine and, more particularly, to an improved method of synthesizing olopatadine which comprises reacting a dibenz[b,e]oxepin-11-one derivative of formula (III) and a suitable reagent under Witting condition, and to the intermediate 11-[(Z)-3-(dimethylamino)-propylidene]-6-11-dihydrodibenz[b,e]-oxepin-2-acet-amide p-toluensulfonate salt. 

Process for preparing olopatadine and/or a pharmaceutically acceptable salt thereof

A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula hydrochloride salt of formula (I) i.e. Cinacalcet.HCl and its intermediate of formula (IX) 

Process for preparing cinacalcet

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Caldiero, Italy

Massimo Verzini