Bracco Imaging S.p.a.

Massimo Sisti

Silvio Aime

Giovanni Battista Giovenzana

Luisella Calabi

Camilla Cavallotti

Giovanni Palmisano

Rolf E Swenson

Luciano Lattuada

Pierfrancesco Morosini

Ramalingam Kondareddiar

Compounds of general formula (I): with substituents as defined herein and their chelates with bi-trivalent ions of the metal elements of atomic numbers 20 to 31, 39, 42, 43, 44, 49, and 57 to 83, and radioisotopes chosen amongPb,Ga,Ga,As,In,In,Y,Ru,Cu,Cu,Fe,Mn,La,Yb,Sm,Ho,Pm,Lu,Pr,Gd,Bi,Sc,Pm,Cu,Ag,Au,Tb,Cr,Tm,Ce,Yb,Y,Dy,Dy,Ru,Ru,Re,Tc,Bi,Bi,Bi,Rh,Pd,Sn,Sn andAu, as well as the salts thereof with physiologically compatible bases or acids.

Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy

Compounds of general formula (I): in which: Ris hydrogen, C&#x2013;Calkyl, C&#x2013;Ccycloalkyl, C&#x2013;Ccycloalkylalkyl, aryl, arylalkyl, or two R1, taken together, form a straight or cyclic C&#x2013;Calkylene group or an ortho disubstituted arylene; Ris hydrogen, C&#x2013;Calkyl, C&#x2013;Ccycloalkyl, C&#x2013;Ccycloalkylalkyl, aryl or aryl alkyl optionally substituted with functional groups which allow conjugation with a suitable molecule able to interact with physiological systems; R, Rand Rare hydrogen, C&#x2013;Calkyl, C&#x2013;Ccycloalkyl, C&#x2013;Ccycloalkylalkyl, aryl, arylalkyl; and their chelates with bi-trivalent ions of the metal elements having atomic number ranging between 20 and 31, 39, 42, 43, 44, 49, and between 57 and 83, and radioisotopes chosen amongPbGaGaAsInInYRuCuCuFeMnLaYbSmHoPmLuPrGdBiScPmCu,Ag,Au,Tb andCr as well as the salts thereof with physiologically compatible bases or acids 

Multidentate aza ligands able to complex metal ions and the use thereof in diagnostics and therapy

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Milan, Italy

Massimo Sisti