Dr. Lo. Zambeletti S.p.a.

Spa Societa Prodotti Antibiotici S.p.a.

Dr. L. Zambeletti Spa

Massimo Signorini

Vittorio Vecchietti

Antonio Giordani

Tiberio Bruzzese

Mario Bergamaschi

Luigi Molteni

Carlo A Fanciano

Gian B Gervasi

Roberta Termini

Attilio Trebbi

Peptide derivatives and their salts with pharmaceutically acceptable acids or bases, having the general formula (I), ##STR1## wherein R=--H, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 acyl, alkoxycarbonyl with C.sub.1 -C.sub.4 alkyl;

Pharmacologically active peptide derivatives and pharmaceutical

A compound of formula (I): ##STR1## or a salt or solvate thereof in which R.CO is an acyl group in which R is of formula (II) ##STR2## in which R.sub.3 is Br, NO.sub.2 or CF.sub.3 ; and, R.sub.1 and R.sub.2 are independently C.sub.1-6 alkyl or together form a C.sub.3-6 polymethylene or alkylene group, is useful for treating pain.

Piperidine analgesics

A compound of formula (I): ##STR1## or a salt or solvate thereof in which R. CO is an acyl group containing a substituted or unsubstituted carbocyclic or heterocyclic aromatic ring, R.sub.1 and R.sub.2 are independently C.sub.1-6 alkyl or together form a C.sub.3-6 polymethylene or alkylene group, and p is 1, 2, 3 or 4, is useful for treating pain.

Cyclic carboxamide derivatives and their use as analgesics

A compound of formula I: ##STR1## or a solvate or salt thereof in which: R is an acyl group containing a substituted or unsubstituted carbocyclic or heterocyclic aromatic ring and R.sub.1 and R.sub.2 are independently C.sub.1-6 alkyl groups or together form a C.sub.3-6 polymethylene or alkenylene group, is useful for treating pain in mammals.

2-acyl-3-aminomethyl-1,2,3,4-tetrahydroquinolines

Novel compounds of formula ##STR1## are described which have antipyretic, analgesic and antiinflammatory activity. R is hydrogen, C.sub.1 -C.sub.3 linear or branched alkyl; R.sub.1 and R.sub.2 are hydrogen, halogen, unsubstituted or esterified hydroxy, alcoxy, and may be the same or different; R.sub.3 is hydrogen, C.sub.1 -C.sub.4 linear or branched aliphatic acyl, unsubstituted or substituted aroyl, alkylaroyl or hetaroyl groups.

Biphenylylalkanoic acid derivatives, methods of preparation and

A process for preparing 1-(3,5-dimethoxy-4-hydroxy phenyl)-2-(N-methylamino) ethanol hydrochloride is described by reacting 2,6-dimethoxyphenol with anhydrous chloral in the presence of a catalyst, hydrolyzing 1-(3,5-dimethoxy-4-hydroxyphenyl)2,2,2-trichloro ethanol and subsequently isolating the 3,5-dimethoxy-4-hydroxyphenyl glyoxal thus obtained; finally, this compound, in the form of the bisulfite, is directly converted to the desired product by amination with methylamine in the presence of hydrogen with a hydrogenation catalyst and the final product is converted into the hydrochloride.

Growing community of inventors

Milan, Italy

Massimo Signorini