Georgetown University

University of Rochester

Navisalute, LLC

Massimo S Fiandaca

Howard J Federoff

Mark E Mapstone

Amrita K Cheema

Ophir Frieder

Xiaogang Zhong

Ramesh Jain

Yuriy Gusev

Embodiments herein relate to biosensors and other elements combined in real-time for health applications that acquire health data of an individual from one or more data streams by a first element and integrate these data through a second element that is configured to predict and/or recognize an interruptive health event and then via one or more successive elements alert one or more providers of a possible interruptive health event, enable the providers to propose one or more effective interventions, communicate directly with the individual and providers and/or caregivers, and/or provide confirmation in the event that effective interventions were made. Embodiments also relate to predicting and recognizing brain attack in real-time by acquiring and integrating health data from one or more data streams, interfacing with one or more providers so that they can propose and/or effect one or more effective interventions, and communicating with an affected individual, providers, and/or caregivers.

Method and system for brain attack triage (BAT)

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.

Metabolic biomarkers for memory loss

The present invention relates to methods of determining if a subject has a decreased risk of suffering from future memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has a decreased risk of suffering from future memory impairment compared to a normal individual.

Metabolic biomarkers for cognitive ability

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's proteomic profile and comparing the value of the subject's proteomic profile with the value of a normal proteomic profile. A change in the value of the subject's proteomic profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.

Protein biomarkers for memory loss

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing the gene expression profile from peripheral blood leukocytes taken from the subject and comparing the value of the subject's gene expression profile with the value of a normal gene expression profile. A change in the value of the subject's gene expression profile, above or below normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.

Genetic markers for memory loss

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise determining the influx of polyunsaturated fatty acids (PUFAs) into the brain from plasma in a test subject and comparing this measured influx to a normal standard influx. An increase in influx of PUFAs from the plasma into the brain is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.

Methods of assessing future memory loss by measuring polyunsaturated fatty acids

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's lipidomic profile, and comparing the value of the subject's lipidomic profile with the value of a normal lipidomic profile. A decrease in the value of the subject's lipidomic profile over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.

Growing community of inventors

Irvine, CA, United States of America

Massimo S Fiandaca