Consiglio Nazionale Delle Ricerche

Mediolanum Farmaceutici S.r.l. Consiglio Nazionale Delle Ricerch

Massimo Pomponi

Mario Brufani

Flaminia Pavone

Alberto Oliverio

Maurizio Marta

Stefano Maiorana

Pier G Pagella

Pier L Rugarli

Carlo Meroni

Claudio Castelland

Claudio Castellano

Riccardo Bernardi

Physostigmine derivatives with acetylcholinesterase inhibition properties, of general formula: ##STR1## in which R is a linear alkyl of from 2 to 20 C. atoms, a branched alkyl, a cycloalkyl or an aryl, when R' is H, or R and R' are linear alkyl of from 2 to 20 C. atoms.

Physostigmine derivatives with acetylcholinesterase inhibition

Organic salts of physostigmine derivatives, having the following general mula: ##STR1## in which R is a linear or branched C.sub.2 -C.sub.12 alkyl or a cycloalkyl or an aryl, and X.sub.- is the anion of an organic acid, the process for their preparation and their pharmaceutical use for acetylcholinesterase inhibition purposes.

Organic salts of physostigmine derivatives

Physostigmine derivatives with acetylcholinesterase inhibition properties, of general formula: ##STR1## in which R is a linear alkyl of from 2 to 20 C atoms, a branched alkyl, a cycloalkyl or an aryl, when r' is H, or R and R' are linear alkyl of from 2 to 20 C atoms.

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Rome, Italy

Massimo Pomponi