Medtronic Vascular, Inc.

Invatec S.p.a

Medtronic, Inc.

Invatec Technology Center Gmbh

Massimo Morero

Carlo Guala

Claudio Silvestro

Jeffery C Argentine

Bradley E Steele

Simone D'Onofrio

Federica Bellucci

Giovanni Scalvini

Francesco Piccagli

Darren Galligan

Cassandra Morris

Kieran Coghlan

Claudia Vimercati

Luca Copeta

Davide Zanetti

Chiara Pedroni

Ludwig Compagnoni

Andrea Sassi

Diane M Haen

Giampiero Nicoli

Marco Miliani

Michele Saputo

A method for coating a medical device includes applying a second layer that includes a second drug on a first layer of on the medical device. The first layer includes a first drug, which may be in crystalline form. By selecting an appropriate solvent use in applying the second layer and appropriate process conditions, the second layer may be applied such that the first drug retains one or more therapeutic properties. For example, the second layer may be applied such that the first drug maintains its crystalline form. The first and second layers may be free of polymer.

Drug-coated medical devices

Angioplasty balloons coated with at least one limus drug, which may be in crystalline form, optionally with at least one excipient, and methods for manufacturing such coated angioplasty balloons.

Drug-coated angioplasty balloons

In some examples, a catheter (e.g., a balloon catheter) includes a guidewire tube extending through a catheter body and a coating on at least a portion of an outer surface of the guidewire tube. In some examples, the coating is an elastomeric coating. The coating is configured to increase friction between the portion of the outer surface of the guidewire tube and an inner surface of the catheter body when the portion of the outer surface contacts an inner surface of the catheter body.

Balloon catheter including a guidewire tube with a friction-increasing outer coating

A variety of nanoparticles or microparticles may be used to treat diseases such as restenosis or blood clots. For example, a nanoparticle or microparticle may include a core having a biodegradable polymer, an exterior having hydrophilic moieties. and a therapeutic agent. The nanoparticles may include targeting moieties that target the nanoparticle or microparticle to an arterial lesion. The nanoparticle or microparticle may include an exterior shell around the core to increase stability of the nanoparticle or microparticle. The nanoparticle or microparticle may include a magnetic particle to allow targeted delivery of the nanoparticle or microparticle via a magnetic field. The nanoparticles or microparticles may be coated on a medical device, such as a catheter balloon or a stent, or may be delivered systemically or locally to patients in need thereof.

Therapeutic nanoparticles for treating vascular diseases

A prosthetic assembly for repairing a target tissue defect within a target vessel region configured includes an exclusion structure sized to substantially bypass target tissue defect, and includes a branch assembly. The branch assembly can include a self-expanding outer branch prosthesis having an inflow region configured to deform to a non-circular cross-sectional-shape when deployed, and a support structure at least partially disposed within the inflow region. The support structure preserves blood flow to the branch vessel while the deformed inflow region inhibits blood leakage between and/or around the prosthetic assembly.

Endoluminal prosthetic assemblies, and associated systems and methods for percutaneous repair of a vascular tissue defect

In some examples, a splittable sheath includes a sheath body defining a lumen configured to receive an expandable balloon of a catheter, and a tab extending from a proximal end or a distal end of the sheath body. The tab includes a major surface having an outer edge defining a serpentine shape. Outward movement of the tab relative to a central longitudinal axis of the sheath body causes splitting of the sheath body.

Splittable sheath

An occlusion bypassing apparatus is disclosed for re-entering the true lumen of a vessel after subintimally bypassing an occlusion in a vessel. The apparatus includes an outer shaft component, an inner shaft component disposed within the outer shaft component, and a needle component slidably disposed within the inner shaft component. The inner shaft component includes a body portion and a needle housing, which is distal to the body portion. The needle housing is less flexible than the body portion. In order to smooth the transition between the body portion and the needle housing, the needle housing includes a transition portion that has a variable flexibility along its length that decreases in a distal direction. A curved distal end of the needle component is distally advanced relative to the inner shaft component to pierce through the intima of the vessel and thereafter enter the true lumen.

Occlusion bypassing apparatus with varying flexibility and methods for bypassing an occlusion in a blood vessel

An occlusion bypassing apparatus for re-entering the true lumen of a vessel after subintimally bypassing an occlusion in a vessel. The apparatus includes an outer shaft component, a needle component, and an inflatable balloon. The outer shaft component has a side port proximal to a distal end thereof and a needle lumen there-through that includes a curved distal portion that terminates at the side port of the outer shaft component. The needle component is configured to be slidably disposed within the needle lumen of the outer shaft component. The inflatable balloon includes a body portion that is disposed distal to the side port of the outer shaft component, and the body portion of the balloon has a flattened profile in an inflated state with first and second chambers that laterally extend from opposing sides of the outer shaft component for stabilizing the apparatus within a subintimal space.

Occlusion bypassing apparatus with a re-entry needle and a distal stabilization balloon

An occlusion bypassing apparatus for re-entering the true lumen of a vessel after subintimally bypassing an occlusion in a vessel. The apparatus includes an outer shaft component having a needle lumen there-through. A proximal end of the outer shaft component is fixed within a handle of the apparatus at a first attachment point. A stabilization tube of the apparatus is disposed within the needle lumen. A proximal end of the stabilization tube is fixed within the handle at a second attachment point that is spaced apart from the first attachment point and an elongated body and a distal end of the stabilization tube are not attached to the outer shaft component. A needle component of the apparatus is configured to be slidably disposed within the stabilization tube and removable therefrom, and the stabilization tube minimizes resistive forces exerted onto the needle component by the outer shaft component.

Occlusion bypassing apparatus with a re-entry needle and a stabilization tube

Catheter devices and methods useable for directing a guidewire from a subintimal position within the wall of an artery into the true lumen of that artery or other applications wherein it is desired to direct a guidewire or other elongate device from one location to another location within a subject's body.

Re-entry catheters and related methods

This invention concerns a guide catheter comprising a hollow tubular body extending along a main longitudinal axis, said tubular body defining at ] least one internal lumen suitable for receiving at least one medical device, the tubular body further defining at least one proximal opening and one distal opening. The tubular body includes a distal portion preformed in such a way as to take on a curved configuration with regard to the main axis. At least the distal portion of the tubular body has a flattened shape that extends prevalently along a main transversal axis, the curvature of said distal portion being created around said main transversal axis.

Catheter guide

A drug eluting angioplasty balloon () suitable to adopt a deployed configuration and a collapsed configuration, the balloon having an outer wall () disposed around a core () defining an axis (X). The balloon () comprising in the collapsed configuration a plurality of folds () that are laid in a tangential direction about the core () and form a plurality of cavities () loaded with a drug (), the cavities () are comprised between the folds (), wherein the folds () originates from distinct longitudinal lines (') along the outer wall (), are arranged in pairs and are circumferentially wrapped about the core () in such a way that a fold of one pair overlaps an adjacent fold of another pair and are wrapped in opposite directions.

Drug eluting balloon for the treatment of stenosis and method of manufacturing the balloon

A blood clot removal device (), comprising a capture member () having a tubular body () of prevailing longitudinal extension and provided with a lumen () extending longitudinally in said tubular body (), at least one proximal portion (), at least one distal portion (), an apical end () of said distal portion (), and a tip (); said at least one distal portion () of said capture member () having at least one helical length () provided, with coils () wrapped in a helical manner forming a pitch (p) therebetween in the longitudinal direction and adapted to the capture of blood clots (); an inner cable () received in said longitudinal lumen () of said tubular body () so as to remain within said tubular body () helical length (), said inner cable () comprising a proximal length () having a proximal maneuvering end () and a distal length () provided with a tip (); wherein said tip () of said inner cable () is secured to said apical end () of said capture member () tubular body (), said tip () being firmly secured to said apical end () so that, when said inner cable () is subjected to a relative movement relative to the capture member () in the proximal direction, said inner cable () brings the tubular body () apical end () closer to the proximal portion thereof, shortening the pitch (p) of said coils () of the helical length () of the blood clot () capture member ().

Growing community of inventors

Roncadelle, Italy

Massimo Morero