Universitá Degli Studi Di Milano-Bicocca

Universita Degli Studi De Milano-bicocca

Massimo Masserini

Francesca Re

Mario Salmona

Gianluigi Forloni

Giulio Sancini

Maria Silvia Sesana

New liposomes are described, comprising: (i) phosphatidic acid and/or cardiolipin; (ii) apolipoprotein E (ApoE) or derivatives thereof. The so modified liposomes, administered systemically, obtain a dramatic in-vivo reduction of the amyloid plaque in the central nervous system, allowing an effective treatment of neurodegenerative diseases, in particular Alzheimer's disease.

Liposomes active in-vivo on neurodegenerative diseases

Novel liposomes are described which are capable of effectively binding beta amyloid peptide and are useful for the treatment, prevention and diagnosis of Alzheimer's disease. Binding ability is provided by the presence in the formulation of particular natural lipids identified by the Applicant. These comprise a constant component, made up of cholesterol and sphingomyelin, and an additional variable component, made up of selected lipids.

Liposomes capable of effectively binding the beta amyloid peptide

Growing community of inventors

Santa Margherita Ligure, Italy

Massimo Masserini