Archimica S.r.l.

Massimo Losa

Marco Frigerio

Giorgio Bertolini

Maurizio Velati

Maurizio Deleo

A novel process for preparing emtricitabine, and more particularly a process for preparing emtricitabine involving the formation and isolation of intermediate compounds in salified form, is described.

Process and intermediates for preparing emtricitabine

A process is disclosed for the stereo-selective preparation of emtricitabine, which allows the desired product to be obtained in good yield and without the use of chromatographic techniques. The process for the production of emtricitabine of the formula (Ia) is characterized by the formation and isolation of intermediate compounds of formula (XIa) in salified form. Emtricitabine is a known antiviral drug.

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Pogliano Milanese, Italy

Massimo Losa