Dana-farber-cancer Institute Inc.

Harvard College

The Brigham and Women's Hospital, Inc.

Massimo Loda

Philip W Kantoff

Frank McKeon

Annie Yang

Lorelei Mucci

Svitlana Tyekucheva

Sabina Signorretti

Christopher Crum

Michaela Bowden

Jonathan E Rosenberg

Joaquim Bellmunt

Carmen Priolo

Saumyadipta Pyne

The present invention relates to compositions and methods and for the diagnosis, prognosis, and treatment of prostate cancer. The invention is based upon the identification of a gene expression signature that predicts the likelihood that prostate cancer will metastasize. Provided is a method of determining whether prostate cancer in a subject will metastasize. Also provided are compositions comprising a prostate cancer-associated gene. Also provided are kits comprising a package with a prostate cancer-associated gene.

Compositions and methods for diagnosing prostate cancer using a gene expression signature

Diagnostic assays for medically classifying cancer patients are provided. The method comprises assessing a tissue sample of the patient for the presence of a copy number gain of chromosome regions 1q23.3 and/or 1q21.2. Copy number gain of chromosome regions 1q23.3 and/or 1q21.2 is indicative of a less favorable prognosis as compared to the prognosis if there was no copy number gain in the same regions.

Chromosome copy number gain as a biomarker of urothelial carcinoma lethality

This application describes the cloning of p63, a gene at chromosome 3q27-29, that bears homology to the tumor suppressor p53. The p63 gene encodes at least six different isotypes. p63 was detected in a variety of human and mouse tissue and demonstrates remarkably divergent activities, such as the ability to transactivate p53 reporter genes and induce apoptosis. Isotopes of p63 lacking a transactivation domain act as dominant negatives towards the transactivation by p53 and p63.

Cell regulatory genes, encoded products, and uses related thereto

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Belmont, MA, United States of America

Massimo Loda