Gentium S.p.a.

Gentium S.r.l.

Nuovo Pignone Holding S.p.a.

Massimo Iacobelli

Laura Ferro

Roberto Porta

Carmelo Carlo Stella

Paul Richardson

Simone Pratesi

Franco Graziani

Alessandro Massimo Gianni

Massimo Alessandro Gianni

Laura Iris Ferro

Aaron Cy Stein

Gunter Eissner

Defibrotide for use in prophylaxis and/or treatment of Graft versus Host Disease (GVHD) in humans is disclosed, preferably in hematopoietic stem cell transplantation (HSCT), more preferably allogeneic hematopoietic stem cell transplantation. Graft versus Host Disease of the invention (GVHD) can be acute aGVHD and/or chronic cGVHD, preferably acute.

Defibrotide for use in prophylaxis and/or treatment of graft versus host disease (GVHD)

The present innovation relates to a novel formulation capable of increasing the amount of stem cells and progenitor cells in circulation in the peripheral blood of a mammal; the formulation is characterized in that it contains defibrotide in combination with at least one haematopoietic factor having the capacity to mobilize haematopoietic progenitors, preferably G-CSF. In one embodiment, the formulation includes two separately administrable formulations, one containing a haematopoietic factor having the capacity to mobilize haematopoietic progenitors and the other containing defibrotide. The formulation is effective to achieve an increase in the number of haematopoietic progenitor cells that is greater than an increase in the number of haematopoietic progenitor cells achieved by the haematopoietic factor alone.

Formulation having mobilizing activity

Defibrotide for use in prophylaxis and/or treatment of Graft versus Host Disease (GVHD)

Formulation having mobilising activity

The use of defibrotide as an anti-tumor agent, alone or in combination with other active ingredients with anti-tumor action, is described.

Formulations with anti-tumour action

A method for the treatment and/or prevention of mucositis due to an antitumour treatment which comprises the administration of a composition containing suiglicotide to a patient in needs of said antitumour treatment.

Use of sulglicotide for the treatment of mucositis

A scraper device for a reciprocating compressor piston rod that comprises at least one scraper ring, provided with at least one lip which faces the surface of the said rod, and a box to contain the scraper ring and for centering on the rod, wherein this scraper ring is produced by means of mechanical processing of deformable plastics materials and wherein this container box is accommodated in support elements with radial play.

Link mechanism of surgical robot

Growing community of inventors

Milan, Italy

Massimo Iacobelli