King Saud University

King Faisal Specialist Hospital and Research Center

Mashooq Ahmad Bhat

Mohamed Abdulrahman Al-Omar

Nawaf Abdulaziz Alsaif

Mohammad Raish

Mushtaq Ahmad Ansari

Syed Hidayathulla

Hatem A Abuelizz

Abdullah Omar Al-Dhfyan

The sulindac derivatives are compounds of the formula: wherein R is one of twenty-five substituted or unsubstituted phenyl substituents; and pharmaceutically acceptable salts thereof. The sulindac derivatives are synthesized by refluxing sulindac hydrazide with appropriately substituted benzaldehydes in the presence of ethanol and catalytic amounts of glacial acetic acid. The sulindac derivatives may be used as active ingredients in pharmaceutical compositions for the treatment of inflammation or inflammatory diseases. The sulindac derivatives may also be used as analgesic and/or gastric sparing agents.

Sulindac derivatives

A dihydropyrimidinone derivative having a chemical structure according to Formula 1: wherein

Dihydropyrimidinone derivatives

Antihepatotoxic agents include dihydropyrimidinone derivatives with 1,4-benzodioxane. The antihepatotoxic agents are compounds having the structural formula represented by Formula 1: wherein each Z independently represents O, N or S; X represents O or S; R represents aryl, substituted aryl, heteroaryl, or substituted heteroaryl; and pharmaceutically acceptable salts of these compounds.

Antihepatotoxic agents

A dihydropyrimidinone derivative includes a compound having a chemical structure according to Formula 1: 

A dihydropyrimidinone derivative includes a compound having a chemical structure according to Formula 1: wherein

Cyclooxygenase inhibitors include compounds of the formula: where R represents phenyl, nitrophenyl, 2-nitrophenyl, 3-nitrophenyl, 4-nitrophenyl, 4-chlorophenyl, 2,4-dichlorophenyl, 3,4-dimethoxyphenyl, 2-methoxyphenyl, 4-hydroxyphenyl, dimethylaminophenyl, 3-methoxyphenyl, 4-ethoxyphenyl, 2,4,5-trimethoxyphenyl, 3,4,5-trimethoxyphenyl, 2,4,6-trimethoxyphenyl, and 2,4-dimethoxyphenyl, 3-hydroxyphenyl, 4-dimethylaminophenyl, or 2,3,4-trimethoxyphenyl.

Cyclooxygenase inhibitors

A method of treating cancer using a dihydropyrimidine derivative includes administering to a patient a therapeutically effective amount of a dihydropyrimidine derivative having the following formula: wherein:

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Mashooq Ahmad Bhat