Novartis Ag

Masha Berkhin

Christopher Bush

Fabian Chen

Gesine Winzenburg

Surya Prakash Ayalasomayajula

Bernd Trueby

The present invention relates to a solid unit oral dosage form comprising sacubitril and valsartan in a 1:1 molar ratio, preferably in the form of the so-called angiotensin receptor neprilysin inhibitor (ARNI) LCZ696, which is a complex salt hydrate of sacubitril, valsartan, and sodium ions, appropriate for use in pediatrics or other patients where low and individual dosing is required or who encounter problems with swallowing e.g. as a result of a disease or because of age, to the manufacture of said solid dosage form and to invention embodiments relating to therapy using said dosage form.

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East Hanover, NJ, United States of America

Masha Berkhin