Takeda Chemical Industries, Inc.

Other

Shiseido Company, Limited

Masazumi Watanabe

Isuke Imada

Mitsuru Kawada

Hirosada Sugihara

Hiroshi Morimoto

Yasushi Sanno

Masao Nishikawa

Michio Motohashi

Masahiro Tajima

Yoshiharu Tsuji

Tsunao Magara

Koji Kobayashi

Shinji Terao

Hirotada Fukunishi

Ichiro Azuma

Yoshitaka Maki

Yuichi Yamamura

Tetsuya Okutani

Eriko Takeoka

Chika Hamada

Yosuke Nakazawa

Kazuhisa Sugimura

Disclosed is a hair revitalizing tonic composition containing a dimethylpropanediol derivative of the formula:

Hair revitalizing tonic composition containing a 2,2-dimethylpropanediol compound and use thereof

The invention relates to a hair revitalizing tonic composition containing, as an active ingredient, at least one lipid derivative of the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and Y are as defined in the specification, and a and b are 0 or 1, as well as its use. Thus, there is provided a hair revitalizing tonic composition having an excellent hair loss prevention and hair revitalizing effect and, moreover, an excellent dandruff and itchy scalp prevention effect.

Hair revitalization tonic composition containing a lipid derivative and

Compounds of the formula: ##STR1## wherein l is an integer of 0 to 18, X is hydrogen, an alkyl having 1 to 4 carbon atoms or a carboxylic acyl having 2 to 4 carbon atoms and Y is a phenylene, a cycloalkylene having 3 to 7 carbon atoms or a group of the formula: ##STR2## in which m is an integer of 0 to 3, and R.sub.1 and R.sub.2 each is an alkyl having 1 to 4 carbon atoms, are novel compounds, possess circulatory disturbance-improving activity and inhibitory activity of the generation and release of SRS-A, and used for prophylactic or therapy of ischemic diseases such as cerebral apoplexy or allergic diseases.

Benzoquinone derivatives, their production and use

A quinone compound of the formula: ##STR1## wherein R stands for an alkyl group of 1 to 22 carbon atoms having at its terminal end a hydroxyl group which may be protected, can be obtained with industrial advantage by allowing a compound of the formula: ##STR2## to react with a peroxide of a carboxylic acid of the formula:

Method of producing quinone derivatives

Novel spirobenzofuranone compounds of the formula: ##STR1## wherein R is a hydrogen atom or a lower alkyl and --X-- is ##STR2## and a pharmaceutically acceptable salt thereof, have gastric secretion inhibitive, antiulcer activities, and are of value as drugs.

Spirobenzofuranones and their use in treating peptic ulcers

Novel compounds of the formulae ##STR1## wherein R represents lower alkyl or lower alkoxy, A represents --CH.sub.2 --, --CO-- or ##STR2## n represents an integer of 1 to 8, X represents hydrogen or hydroxyl which may be protected and Y represents hydroxyl which may be protected, and their esters show an excellent action on the lysosomal membranes of cells, and exhibit excellent pharmacological activities such as physiologic host defense control activity, especially immuno-potentiating activity.

Aralkyl carboxylic acid compounds in compositions for potentiating

Compounds of the formula ##STR1## wherein A is methylene or carbonyl, n is an integer of 2 to 21, inclusive, and R is hydrogen or lower alkyl, are effective for the prophylaxis or treatment of mammals suffering from fibrosis due to excessive collagen accumulation.

Antifibrotic agent

A compound of the general formula ##STR1## wherein n is an integer of 10 to 21, inclusive; R is H or lower alkyl having 1 to 4 carbon atoms has pharmaceutical activities such as hypotensive, tissue metabolism stimulating, immuno-regulatory, lysosomal membrane stabilizing and SRS-A production inhibitory activities and is useful as a heart failure remedy, cerebral circulation disturbance remedy, immuno-regulator, and antiallergic drug.

Quinone carboxylic acids and ester derivatives

Aralkyl carboxylic acid compounds

A mammal suffering from allergic disease due to SRS-A, such as skin symptoms, asthma, rhinitis, etc. is treated by administering to said mammal an effective amount of a compound of the formula: ##STR1## wherein R is methoxy or methyl, or two R's taken together represent --CH.dbd.CH--CH.dbd.CH--; and n is an integer of 4 to 22.

Antiallergic agent

Novel 7-acetylspirobenzofuranone compound of the formula: ##STR1## has gastric secretion inhibitive, antiinflammatory and analgesic activities, and is of value as drugs.

7-Acetylspirobenzofuranone compound

Novel spirobenzofuranone compounds of the formula: ##STR1## have gastric secretion inhibitive, antiinflammatory and analgesic activities, and are of value as drugs.

Spirobenzofuranone compounds

Novel spiro compounds of the formula: ##STR1## wherein Ring A represents a benzene ring or a naphthalene ring, said rings being unsubstituted or substituted by at least one of lower alkyl, nitro, halogen, amino which may optionally be substituted, hydroxyl which may optionally be substituted, acyl, sulfamoyl, carboxyl, lower alkoxycarbonyl, carbamoyl which may optionally be substituted, ureido which may optionally be substituted, thioureido which may optionally be substituted, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, aminomethyl which may optionally be substituted, cyano and phenyl, have gastric secretion inhibitive, anti-inflammatory and analgesic activities, and are of value as drugs.

Novel compounds of the formula ##STR1## wherein R represents lower alkyl or lower alkoxy, A represents --CH.sub.2 --, --CO-- or ##STR2## n represents an integer of 1 to 8, X represents hydrogen or hydroxyl which may be protected and Y represents hydroxyl which may be protected, and their esters show an excellent action on the lysosomal membranes of cells, and exhibit excellent pharmacological activities such as physiologic host defense control activity, especially immuno-potentiating activity.

6-Hydroxy-1,4-benzoquinone compounds

The aqueous preparation such as an aqueous solution, a water-in-oil emulsion, in which a water-soluble salt of the quinonyl acid derivative of the formula: ##STR1## [wherein each R is a lower alkoxy group having 1 to 4 carbon atoms or the two R's, taken together, represent a group of --CH.dbd.CH--CH.dbd.CH--; --A--COOH means ##STR2## when both R's are lower alkoxy groups, or --(CH.sub.2).sub.n COOH (wherein n is an integer from 1 to 8) when two R's, taken together, represent a group of --CH.dbd.CH--CH.dbd.CH--] is dissolved in aqueous phase, shows an excellent immunoregulatory activity in animals including human being.

Growing community of inventors

Kawanishi, Japan

Masazumi Watanabe