Daiichi Pharmaceutical Co., Ltd.

Daiichi Seiyaku Co., Ltd.

Other

Masazumi Imamura

Isao Hayakawa

Shohgo Atarashi

Shuichi Yokohama

Nobuyuki Higashihashi

Katsuichi Sakano

Masayuki Ohshima

Youichi Kimura

Akiko Itai

A method of predicting a biological function of one or more query proteins having predetermined or predictable steric structures using a three-dimensional structure database comprising:

Method of predicting functions of proteins using ligand database

A compound of formula I, having antibacterial activity and a pharmaceutical composition containing the compound of formula I: ##STR1## wherein Q represents a partial structure of formula II: ##STR2## wherein all substituents are defined in the specification.

Spiro compound

The present invention relates to spiro compounds of general formula I: ##STR1## wherein the substituents are herein below defined. The present invention relates to antibacterial spiro compounds which are of value as drugs for humans, veterinary drugs or drugs for use in fish culture or as preservatives, and to antibacterial compositions containing one or more of the same compounds as active ingredients.

An optically action pyridobenzoxazine derivative, a process for preparing the same and a novel intermediate useful for preparing the optically active pyridobenzoxazine derivative are disclosed. The optically active pyridobenzoxazine derivative possesses increased antimicrobial activity and reduced toxicity. The intermediate is useful for preparing such optically active pyridobenzoxazine derivatives such as Ofloxacin and anolog compounds.

Optically active pyridobenzoxazine derivatives and intermediates thereof

Optically active pyridobenzoxazine derivatives and anti-microbial use

Novel 4-oxoguinoline-3-carboxylic acid derivatives having the formula ##STR1## wherein X.sup.1 represents a halogen or hydrogen atom, X.sup.2 represents a halogen or hydrogen atom, X.sup.3 represents a halogen atom, and R.sup.1, R.sup.2 and R.sup.3 each represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, and physiologically acceptable salts thereof, are disclosed. These compounds have excellent antibacterial activity against gram-positive and gram-negative bacteria and beneficial pharmacokinetic properties.

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Chiba, Japan

Masazumi Imamura