Other

Tobishi Yakuhin Kogyo Kabushiki Kaisha

Masayuki Yuasa

Tsutomu Inoue

Takashi Inaba

Tadashi Morita

Osamu Sakuma

Isao Umezawa

Tomohiko Ishikawa

Tadashi Toshioka

Masatoshi Hagiwara

Hiroyoshi Hidaka

Kenji Naitoh

Akira Endo

Shinpei Kidokoro

Horoyoshi Hidaka

Kenji Naito

Novel quinoline sulfonamino derivatives having a vessel smooth muscle relaxation activity as well as a platelet agglutination inhibitory activity and inhibitory activity to protein kinase A, myosin light chain kinase, proteinkinase C, and calmodulindependent proteinkinase II, but having little action or cardio function; a process for the production of the derivatives, and a pharmaceutical composition containing the derivative.

Compound having vessel smooth muscle relaxation activity

Derivatives of physiologically active substance ML-236B and process for

Derivatives of isoquinoline (and naphthalene) sulfonamides

Novel compounds represented by the formula: ##STR1## wherein R.sub.1 represents an alkyl group having 1 to 3 carbon atoms, R.sub.2 represents an amino group or a group of formula ##STR2## in which R.sub.4 represents an alkyl group having 1 to 3 carbon atoms, R.sub.5 represents an alkyl group having 1 to 3 carbon atoms or may combine with R.sub.6 to form a five or six membered ring containing 4 to 5 carbon atoms, R.sub.6 represents a hydrogen atom or may combine with R.sub.5 to form a five or six membered ring containing 4 to 5 carbon atoms, R.sub.3 represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms or a halogen atom, X represents a carbonyl group or a methylene group, Y represents a sulfur atom or a vinylene group and pharmaceutically acceptable salts thereof which exhibit a vasodilating activity and inhibitory activity for platelet aggregation. Thus, they are useful as therapeutic agents for treatment of angina pectoris, hypertension, throbosis and the like.

Novel compounds exhibiting a vasodilating activity and inhibitory

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Akishima, Japan

Masayuki Yuasa