Kotobuki Seiyaku Co. Ltd.

Masayuki Yokota

Tsuyoshi Tomiyama

Akira Tomiyama

Takashi Yanagisawa

Shuuichi Wakabayashi

Masafumi Yasunami

Rei Koyama

Satoko Uchibori

Hiromi Hayashi

A series of new azulene derivatives are disclosed, which are represented by the following formula; ##STR1## wherein: R.sub.1 is hydrogen atom, lower alkoxycarbonyl group, carboxy group, halogen atom, lower alkyl group, phenyl group or lower alkanoyl group; R.sub.2, R.sub.3 and R.sub.4 are hydrogen atom, lower alkyl group, lower alkoxy group or halogen atom; X is lower alkyl group or amino group. The compounds of the present invention are useful for treatment of inflammation.

2-phenylazulene derivatives and a manufacturing method of these compounds

A series of new azulene analogues are disclosed, which are represented by the following formula: ##STR1## wherein: R.sub.1 is --COOH, --COOR.sub.4 (R.sub.4 represents a lower alkyl), --CH.dbd.CH--COOH, --CH.sub.2 --COOH or --SO.sub.3 H;

Azulene derivatives as thromboxane A.sub.2 and prostaglandin

New agents of carbacyclin derivatives are disclosed, which are represented by the following formula: ##STR1## wherein A is a --CH.dbd.CH-- or --C.tbd.C-- group. B is a substituted or unsubstituted indanyl group, substituted or unsubstituted benzodioxanyl group, substituted or unsubstituted benzodioxolanyl group or 2,3,5,6,7, 8-hexahydrobenzodioxanyl group. D is --CH.sub.2 -- or --O--. .about.OH group represents .alpha. or .beta. configuration of OH group; and ##STR2## These compounds are useful as anit-ulcer, anti-hypertensive or anti-thrombotic agents.

Carbacyclin derivatives, method of manufacturing the same and

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Sakaki, Japan

Masayuki Yokota