Eisai Company, Limited

Eisai Inc.

Masayuki Tanaka

Makoto Okita

Isao Yamatsu

Takeshi Suzuki

Mitsuaki Miyamoto

Yoshinori Sakuma

Toshihiko Kaneko

Shigeru Souda

Yoshimasa Machida

Shigeki Hibi

Seiichiro Nomoto

Seiichi Kobayashi

Katsuya Tagami

Yasushi Okamoto

Motohiro Soejima

Kouichi Katayama

Tatsuya Yoshiuchi

Hiroshi Shirota

Kenichi Chiba

Hideki Ono

Ryoichi Hashida

Hideto Ohhara

Makoto Kaino

Koji Yamada

Masaki Goto

Katsuhiro Moriya

Hideki Sakurai

Koichi Katayama

Kokichi Harada

Keizo Sato

Yukio Nishizawa

Shinya Abe

Tetsuya Kawahara

Kenji Hayashi

Naoki Asakawa

Kozo Akasaka

Satoshi Katayama

Naoya Kishi

Yumi Yokoyama

Nitrogen-containing tricyclic compounds and drugs containing the same

A high-performance liquid chromatography apparatus and a process for conversion of mobile phase, enabling a trace amount of sample for NMR analysis to be efficiently separated and prepared, includes steps of separating a target ingredient from the sample by the high-performance liquid chromatography, trapping the target ingredient in a trapping column using a different mobile phase, replacing water by deuterium oxide and eluting this target ingredient from the trapping column using deuterated solvent other than deuterium oxide.

HPLC apparatus for fractioning and preparing sample for NMR spectrometry and method of changing mobile phase

A phenothiazine, acridan, acridone oxime, acridone hydrazone and dibenzodiazepine derivative represented by formula (I)

Naphthalene derivatives of the formula: ##STR1## wherein R.sup.1, represents a hydrogen atom, a lower alkyl group or an acyl group; R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroaryllakyl group; R.sup.3 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxyl group, a carboxyalkyl group, an aminoalkyl group, or a cyano group; R.sup.6 is C.sub.1-6 alkyl; and m is 0 or an integer of from 1 to 2 useful in treating autoimmune diseases are disclosed.

Naphthalene derivative

A naphthalene derivative having the formula is new and useful for medicine. ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;

A naphthalene derivative having the formula is new and useful for medicine. ##STR1## [wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;

A benzothiazol compound having the formula is disclosed and is effective to inhibit the production of leukotriene. It is useful against allergy, asthma, affections of the skin, allergic rhinitis and affection of a cardiovascular system. ##STR1## in which R20 is ester or amide and --NR5R6 is amino in variety.

Benzothiazole derivative

Growing community of inventors

Ibaraki, Japan

Masayuki Tanaka