Osaka University

Gc Corporation

Hiroshima University

Masayuki Okazaki

Hiroshi Egusa

Daisuke Usuki

Yoshinosuke Hamada

Hideaki Shintani

Nariaki Matsuura

Kenichi Shirai

Yasuhiro Yoshida

Yoshitoshi Kaneda

Bart Van Meerbeek

It is found that a SVVYGLR peptide (SEQ ID NO: 1) can promote proliferation of mesenchymal cells such as marrow-derived mesenchymal stem cells and dental pulp cells. A carbonate apatite-collagen sponge containing the SVVYGLR peptide (SEQ ID NO: 1) is useful as a biomaterial for the regeneration of bone marrow or dental pulp. It becomes possible to provide a skeletal system biomaterial which is capable of promoting the proliferation of the mesenchymal cells and is useful as artificial bone marrow or artificial dental pulp for repairing a defect in a bone marrow tissue or a dental pulp tissue.

Mesenchymal cell proliferation promoter and skeletal system biomaterial

A method of cleaning of an inorganic filler, upon which the inorganic filler used in resin materials for industrial or biological use, particularly dental resin restorative materials, can be more firmly bound to a resin matrix as a substrate, as well as a method of surface processing of the inorganic filler, are provided. The inorganic filler surface is cleaned with an aqueous solution of a peroxo acid and/or a peroxo acid salt, washed with water, and then cleaned with an organic solvent. Further, the cleaned inorganic filler is subjected to a silane coupling processing, thereby the inorganic filler being processed.

Method of cleaning and surface processing of inorganic filler utility

Growing community of inventors

Hiroshima, Japan

Masayuki Okazaki