Takeda Chemical Industries, Inc.

Masayuki Muroi

Seiichi Tanida

Tsuneo Kanamaru

Mitsuko Asai

Eiji Higashide

Toru Hasegawa

Tsuneaki Hida

Takenori Ishimaru

Susumu Shinagawa

Yukimasa Nozaki

Makoto Kida

A novel compound of the formula (I): ##STR1## wherein R.sub.1 is esterified carboxyl; R.sub.2, R.sub.3 and R.sub.4 are the same or different and are hydrogen or alkyl; A is formyl, hydroxyiminomethyl or carboxyl; and X is hydrogen or halogen, or a salt thereof, which is useful as an aromatase inhibitor or an intermediate of its production. Processes for producing the compound of the formula (I) and an aromatase inhibitor containing as an active component the compound of the formula (I) wherein A is formyl and X is hydrogen or, a salt thereof as well as Penicillium funiculosum capable for producing the compound (I) wherein R.sub.1 is carboxyl, R.sub.2, R.sub.3 and R.sub.4 are hydrogen and X is formyl are also disclosed.

Physiologically active substance TAN-931, its derivatives, their

The present invention relates to a compound of the formula: ##STR1## wherein X is hydroxyl group or hydrogenatom, or a salt thereof. The compound (I) has an acitivity to inhibit angiogenesis, which is useful for prophylaxis and therapy of various diseases accompanying abnormally increased angiogenesis, especially of tumors.

TAN-1120, its derivatives, production and use thereof

A novel compound of the formula (I): ##STR1## wherein R.sub.1 is optionally esterified or amidated carboxyl; R.sub.2, R.sub.3 and R.sub.4 are the same or different and are hydrogen or alkyl; A is formyl, hydroxyiminomethyl or carboxyl; and X is hydrogen or halogen, or a salt thereof, which is useful as an aromatase inhibitor or an intermediate of its production. Processes for producing the compound of the formula (I) and an aromatase inhibitor containing as an active component the compound of the formula (I) wherein A is formyl and X is hydrogen or, a salt thereof as well as Penicillium funiculosum capable for producing the compound (I) wherein R.sub.1 is carboxyl, R.sub.2, R.sub.3 and R.sub.4 are hydrogen and X is formyl are also disclosed.

Physiologically active substance Tan-931, its derivatives, their

The present invention relates to an aromatase inhibiting composition which contains a compound of the formula: ##STR1## wherein R is hydroxy, lower alkoxy or amino which may be substituted by lower alkyl; R.sup.1 is hydrogen or lower alkyl; and A is hydrogen, a group of the formula ##STR2## in which R.sup.2 is hydroxy, lower alkoxy or amino which may be substituted by lower alkyl and R.sup.3 is hydrogen or lower alkyl, or a group of the formula ##STR3## in which R.sup.4 and R.sup.5 are independently hydrogen or lower alkyl, or a salt thereof. The present composition is useful in the prevention and treatment of estrogen-dependent diseases, such as breast cancer.

Naphthopyran derivatives and use thereof

A novel compound of the formula (I): ##STR1## wherein R.sub.1 is optionally esterified or amidated carboxyl; R.sub.2, R.sub.3 and R.sub.4 are the same or different and are hydrogen or halogen or alkyl; A is formyl, hydroxyiminomethyl or carboxyl; and A is hydrogen or halogen, or a salt thereof, which is useful as an aromatase inhibitor or an intermediate of its production. Processes for producing the compound of the formula (I) and an aromatase inhibitor containing as an active compound the compound of the formula (I) wherein A is formyl and X is hydrogen or, a salt thereof as well as Penicillium funiculosum capable for producing the compound (I) wherein R.sub.1 is carboxyl, R.sub.2, R.sub.3 and R.sub.4 are hydrogen and X is formyl are also disclosed.

Physiologically active substance tan-931, its derivatives, their

The present invention relates to a compound FA-4283 or its derivative of the formula: ##STR1## wherein R is hydrogen or lower alkyl, and 3,4- and 3',4'-double bond may be saturated with hydrogens, and the method of production thereof. The compound (I) of the invention has an action of inhibiting fatty acid synthesis, thus being useful as an agent for prophylaxis and improvement of disorders of glucose and lipid methabolism.

2-oxo-5-methyl-6-[4-heptene]-2H-pyrano[3,2-c]pyridine

A compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents hydrogen or methyl and X is ##STR2## provided that when R.sub.1 is hydrogen, R.sub.2 is hydrogen or methyl and X is ##STR3## and when R.sub.1 is methyl, R.sub.2 is methyl and X is ##STR4## is produced by cultivating a a microorganism belonging to the genus Streptomyces in a culture medium. Said compound is useful as an antimicrobial agent and so forth.

Antibiotic TAN-420

Macbecin derivatives are produced by cultivating a microorganism of the genus Actinosynnema in a culture medium. The Macbecin derivatives are useful as antibacterial, antifungal or antiprotozoal agent.

Macbecin derivatives and their production

Macbecin derivatives

Macbecin derivatives are produced by bringing Macbecins into contact with a microorganism, or its processed matter, of the genus Streptomyces or Nocardia. The Macbecin derivatives are useful as antibacterial, antifungal or antiprotozoal agent.

A novel antibiotic C-14482 A.sub.1 is produced by cultivating a microorganism belonging to the genus Nocardia and capable of producing Antibiotic C-14482 A.sub.1 is a culture medium, whereby Antibiotic C-14482 A.sub.1 is elaborated and accumulated in the culture medium and recovering the same antibiotic. Antibiotic C-14482 A.sub.1 is useful as a germicide or disinfectant.

Culture of Nocardia ATCC 31309

A novel antibiotic C-14482 A.sub.1 is produced by cultivating a microorganism belonging to the genus Nocardia and capable of producing Antibiotic C-14482 A.sub.1 in a culture medium, whereby Antibiotic C-14482 A.sub.1 is elaborated and accumulated in the culture medium, and recovering the same antibiotic. Antibiotic C-14482 A.sub.1 is useful as a germicide or disinfectant.

Antibiotic C-14482 A.sub.1 and method for producing same

Novel antibiotics C-14482 B.sub.1, B.sub.2 and B.sub.3 are produced by cultivating a microorganism belonging to the genus Nocardia and capable of producing Antibiotics C-14482 B.sub.1, B.sub.2 and/or B.sub.3 in a culture medium, whereby Antibiotics C-14482 B.sub.1, B.sub.2 and/or B.sub.3 are elaborated and accumulated in the cultured broth and are recovered. Antibiotics C-14482 B.sub.1, B.sub.2 and B.sub.3 are useful as a germicide or disinfectant, respectively.

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Suita, Japan

Masayuki Muroi