The University of Tokyo

Kyocera Corporation

Kyocera Medical Corporation

Tokyo Medical and Dental University

Tokyo Institute of Technology

Bmg Inc.

Japan Medical Materials Corporation

Takatori, Yoshio

Ishihara, Kazuhiko

Nakamura, Kozo

Kawaguchi, Hiroshi

Moro, Toru

Masayuki Kyomoto

Kazuhiko Ishihara

Toru Moro

Hiroshi Kawaguchi

Kozo Nakamura

Yoshio Takatori

Kenichi Watanabe

Sakae Tanaka

Tomohiro Konno

Noboru Yamawaki

Shintaro Honda

Yasuhiko Iwasaki

Makoto Kondo

Takashi Nakamura

Masahiko Hashida

Tomoaki Sugiyama

Takeshi Nizuka

Toshiyuki Ikoma

Takashi Sasaki

Michimasa Kamo

Hiroaki Takadama

Masami Hashimoto

Suonghyu Hyon

Hiroaki Igashira

Shihori Yamane

Kenichi Saiga

Yugo Fukuyama

An estimation apparatus includes an input unit and an approximator. Input information including an image in which a bone appears is input into the input unit. The approximator is configured to determine an estimation result related to bone density of the bone from the input information. The approximator includes a learned parameter to obtain the estimation result.

Estimation apparatus, estimation system, and computer-readable non-transitory medium storing estimation program

A prediction device includes a first prediction unit that outputs first prediction information regarding a joint at a second point in time after a predetermined period of time from a first point in time, from a medical image showing the joint of a subject at the first point in time. The first prediction unit includes a first prediction model capable of estimating the first prediction information from the medical image.

Prediction device, prediction system, control method, and control program

A resin molded body, includes: a polyolefin element including a crystalline region and an amorphous region; and a hydrophilic polymer contained in a region from a surface of the polyolefin element to part of the amorphous region located below the surface. Or, a method for producing a resin molded body, includes: preparing a polyolefin element including a crystalline region and an amorphous region; forming a coating of a hydrophilic polymer on a surface of the polyolefin element; and applying heat treatment to the polyolefin element on which the coating of the hydrophilic polymer is formed, wherein by applying the heat treatment, the coating of the hydrophilic polymer is immersed in a region from the surface to part of the amorphous region located below the surface.

Resin molded body and method for producing resin molded body

A resin molded body includes: a polyolefin element formed of polyolefin, including a crystalline region and an amorphous region; and a hydrophilic copolymer contained in at least part of a surface of the polyolefin element, the hydrophilic copolymer including a copolymer of 2-methacryloyloxyethyl phosphorylcholine (MPC) of 45% or greater on a mole fraction basis and at least one other monomer. In the resin molded body, the MPC polymer is immersed through the surface by applying heat treatment.

The object of the present invention is to provide an antibacterial material capable of sustaining antibacterial properties for a long time. The object can be solved by a silver-containing calcium phosphate sintered body having silver particles therein, wherein an average particle diameter of the silver particles is 0.01 to 0.5 &#x3bc;m.

Silver-containing calcium phosphate sintered body and method for producing same

To provide a prosthetic member that is less likely to degrade its mechanical properties even when using it in the presence of squalene, and a method of producing the same. The prosthetic member in the present invention includes a substrate exhibiting excellent antioxidant properties and including an antioxidant and a polymer material, and a polymer film(s) covering a surface of the substrate and comprising a (meth)acrylate compound. The method for producing the prosthetic member in the present invention includes the steps of: forming a substrate comprising an antioxidant and a polymer material, cleaning a surface of the substrate with a cleaning liquid, and covering the cleaned surface of the substrate with a polymer film(s) comprising a (meth)acrylate compound.

Antioxidative prosthetic member

An object of the present invention is to provide a method of producing a bearing material having excellent wear-resistance and oxidation resistance. The method of producing a bearing materialaccording to the present invention comprises molding a substratecontaining a radical scavenger and a polymer material; washing at least a partof the substratewith a washing liquid; and grafting a polymer chain having a phosphorylcholine group from at least the partof the surface after washing so as to form a polymer filmon at least the part of the surface.

Bearing material and method of producing the same

An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.

Medical device and method for producing the same

The object of the present invention is to provide a sliding member, a prosthesis and a method of producing the sliding member, which can suppress production of abrasive wear debris by suppressing friction of the sliding section, and also can maintain satisfactory mechanical characteristics in vivo. A sliding member comprising: a substratecapable of forming hydroxyl groups; and a biocompatible material layerlaminated on appropriate sections of the substrate, wherein hydroxyl groups are formed on at least a required section of a surface of the substrateby surface treating to form a surface-treated layer, while the biocompatible material layeris formed from a polymer containing phosphorylcholine groups, and wherein the substrateand the biocompatible material layerare joined via a binder layerformed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively.

Biocompatible and low-abrasion member, and artificial joint using the same and method of producing the same

The present invention provides a bearing material that is excellent in durability and is capable of maintaining wear resistance over a long period of time. The bearing material of the present invention is a high wear-resistance bearing materialfor being used under a humid environment comprising: a base bodymade of a polymer material having a methylene group; and a polymer layercovering a bearing surfaceof the substrate, the polymer layercomprising polymer chains which have a phosphorylcholine group and are grafted from the bearing surface, wherein a phosphoric index of the sliding surfacewhich is calculated by dividing a peak intensity of phosphate group in an infrared spectrum measured on the sliding surface by a peak intensity of the methylene group therein is not less than 0.28.

High wear-resistant bearing material and artificial joint replacement using the same

The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.

Biomaterial, joint prosthesis using the biomaterial and method of producing the same

The present invention is directed to a method for replacing a nucleus pulposus in an intervertebral disk, which method includes: providing a spinal intervertebral disk replacement molded-dry-product for nucleus pulposus including a polyvinylalcohol gel having a percentage of saturated water content of 18 to 50 wt % before irradiation and being irradiated with &#x3b3; ray at an intensity of 20 to 100 kGy; and inserting the spinal intervertebral disk replacement molded-dry-product for nucleus pulposus into a prosthetic space inside an anulus fibrosus through an incision opening of the anulus fibrosus, wherein the molded-dry-product changes its shape into an almost cylindrical or almost elliptically cylindrical shape so that a hollow region comes into existence at a shape deformation rate of 150 vol % or more and at a volume swelling ratio of 135 vol % or less by water absorption.

Spinal intervertebral disk replacement material for nucleus pulposus and production method thereof

Disclosed is a graft polymerization method which has solved problems involved in use of a solvent, a radical initiator and high-energy radiation when a monomer is graft-polymerized on the surface of a polymer base. The graft polymerization method is characterized in that a polymerization product is obtained by immersing a polymer base (i) having a ketone group on the surface into a reaction system containing a monomer (ii) and then irradiating the polymer base (i) with light so that polymerization of the monomer starts from the surface of the polymer base (i).

Graft polymerization method and product obtained thereby

Disclosed is a sliding member with excellent durability and capable of maintaining wear resistance over a long period of time. Further disclosed is an artificial joint member for which the film thickness of the polymer base material is reduced. Further disclosed is an artificial joint which is capable of demonstrating high lubricity, biocompatibility, and resistance to dislocation after introduction into the body. Further disclosed are a medical appliance material and a medical appliance which demonstrate excellent biocompatibility. The sliding material or the medical appliance material is formed by a polymer layer or a biocompatible material layer (B) being provided by coating at least a portion of the surface of a polymer base material (A), the surface of which has a ketone group, and the polymer layer or biocompatible layer (B) is characterized by being formed by surface graft polymerization, wherein the polymer base material (A) is immersed in a reaction system which contains a monomer (C), the polymer base material (A) is exposed to light, and polymerization of the monomer is initiated from the surface of the polymer base material (A). Using the sliding material or medical appliance material, an artificial joint member, an artificial joint, a medical appliance material, and a medical appliance are manufactured.

Growing community of inventors

Osaka, Japan

Masayuki Kyomoto