Mitsubishi Electric Corporation

Astellas Pharma Gmbh

National Cancer Center

Mitsubishi Denki Kabushiki Kaisha

Konami Digital Entertainment Co., Ltd.

Masayuki Komatsu

Masaaki Yabe

Satoshi Minezawa

Yuki Ogawa

Hirotoshi Yano

Ichiro Maruyama

Shinji Nakamura

Shiro Suzuki

Satoshi Endo

Hiroki Sasaki

Kaori Sato

Yoshiyuki Tenda

Masatoshi Yuri

Fumiko Chiwaki

Takashi Arai

Takeshi Tsutsumi

Daisuke Yamajuku

Hiroaki Ushirosako

Tadaaki Sakamoto

Akihiro Toda

Yuko Kusuzaki

Yoshiaki Koizumi

Toshiaki Yoshikawa

Takashi Ogawa

Keisuke Takayama

Shigenori Yagi

Naoyuki Hibara

Daisuke Iizawa

Hiroki Shirai

Yoshinori Nakajima

Takashi Inubushi

Yoshihiko Narita

Kenichiro Tanaka

Takashi Ogino

Kazunori Hirayama

Satoshi Hanai

Kanji Mizuno

Yoshiki Satake

Hiroshi Naraoka

Tadashi Minamino

Satoshi Kizawa

Satoshi Nomura

Tadahiko Inaba

Naoki Barada

Kei Yanagimoto

An objective of the present invention is to provide an anti-TSPAN8/anti-CD3 bispecific antibody and an anti-TSPAN8 antibody usable in treatment or prevention in human. A human monoclonal antibody producing mouse was immunized with a peritoneal disseminated cancer cell isolated from a patient, to obtain an antibody 16B11 and an antibody 16B12 that selectively bind to a peritoneal disseminated cancer cell. These antibodies were anti-TSPAN8 antibodies that bind to the region from amino acid positions 126 to 155 of TSPAN8 and exhibited strong binding activity to TSPAN8 expressed in the peritoneal disseminated cancer cell. Further, an anti-TSPAN8(16B11)-anti-CD3 bispecific antibody produced based on the sequence of 16B11 exhibited a cytotoxic activity against the TSPAN8-expressing cancer cell in vitro, exerted an anti-tumor action on TSPAN8-expressing cancer cell-bearing mice in vivo, and extended the lifetime of peritoneal dissemination model mice.

Anti-TSPAN8/anti-CD3 bispecific antibody and anti-TSPAN8 antibody

An object of the present invention is to provide an anti-CLDN4/anti-CD137 bispecific antibody usable in treatment of cancer. An anti-CLDN4/anti-CD137 bispecific antibody produced using an anti-CLDN4 antibody binding to CLDN4 and an anti-CD137 antibody binding to CD137 had agonistic activity for CD137, promoted production of interferon γ by a T cell, and exhibited cytotoxic activity against a cancer cell expressing CLDN4 on a cell surface thereof. Besides, it was shown that the anti-CLDN4/anti-CD137 bispecific antibody can be safely administered to monkeys. Therefore, the anti-CLDN4/anti-CD137 bispecific antibody is usable in treatment of human cancer.

Anti-CLDN4/anti-CD137 bispecific antibody

In a control device, an instruction acquirer acquires an instruction to suppress in a specified period supplying of generated power generated by power generator installed in a power-consuming area to a commercial electrical power system. Upon the instruction acquirer acquiring the instruction, a water heater controller commands a water heater installed in the power-consuming area to perform a water heat-up operation when a predetermined condition is satisfied in the specified period.

Control device, control method for water heater, and program

A connection management device is communicatively connected to a plurality of server devices. A receiver receives from a terminal device a request for connection to one of the plurality of server devices. A location information extractor extracts, from the request for connection, location information indicating a location where the terminal device exists. A region determiner determines, based on the extracted location information, a region where the terminal device exists. A connection destination determiner determines, based on the determined region, which of the plurality of server devices is the server device to which the terminal device is to connect. A transmitter transmits to the determined server device the request for connection received from the terminal device.

Connection management device for connection to secure server connection management system for connection to secure server connection management method for connection to secure server and program

A settings data storage stores unique serial numbers and information regarding a plurality of patterns for alternately switching between normal operation for operating at high capacity and suppressed operation for operating at low capacity each unit time. A pattern specifier determines information for a pattern set in accordance with even and odd serial numbers. A water-heating heat amount determiner determines a heat amount necessary for water heating. A water heating scheduler establishes a water heating plan based on information regarding the pattern determined by the pattern determiner and the water-heating heat amount as determined by the water-heating heat amount determiner. A water heating controller alternately switches between normal operating and suppressed operation to heat water in accordance with the water heating plan established by the water heating scheduler.

Hot-water supply unit and hot-water supply system

In an appliance control system, a receiver receives, from a terminal device used by a first user, an instruction for remotely controlling an appliance installed in a home. A determiner determines whether a second user is present in a location in which an appliance-to-be-instructed is installed. When it is determined that the second user is not present in a location in which the appliance-to-be-instructed is installed, an appliance controller controls the appliance on the basis of the instruction. On the other hand, when it is determined that the second user is present in the location in which the appliance-to-be-instructed is installed, the appliance controller does not control the appliance.

Appliance control system, home controller, remote control method, and recording medium

An apparatus control system includes smart glasses worn by a user, a home electrical apparatus that is a target of control, and a controller that controls the home electrical apparatus. In the smart glasses, a sensor detects information including at least one of image information, motion information, biological information, or environmental information. A communicator transmits to the controller the information detected by the sensor. The controller, based on the information detected by the sensor, determines a recommended operation indicating operational content recommended with respect to a recommended apparatus, and transmits the determined recommended operation to the smart glasses. The communicator receives the recommended operation transmitted from the controller. The display displays a candidate group for selection of the home electrical apparatus along with a recommended operation received from the communicator.

Apparatus control system

Upon receiving a command signal transmitted from a remote controller (), based on contents of the received command signal, a setter of an electrical apparatus sets a time interval for prohibition of operation from an operation terminal. During the time interval set by the setter, an operation controller of the electrical apparatus does not control based on the received command signal, even if a command signal transmitted from the operation terminal is received via a HEMS controller.

Control system, control method, electrical apparatus, control device, and program

A standardized information acquirer acquires standardized information from an electric device. A standardized telegraphic message sender sends a standardized telegraphic message including the standardized information to a communication device. An unstandardized information acquirer acquires unstandardized information from the electric device. A standardized telegraphic message receiver receives the standardized telegraphic message including the standardized information. An electric device determiner determines whether the electric device meets a specific condition based on the standardized information included in the received standardized telegraphic message. When the electric device is determined to meet the specific condition, an unstandardized telegraphic message sender sends the unstandardized telegraphic message including the unstandardized information. An unstandardized telegraphic message receiver receives the unstandardized telegraphic message including the unstandardized information.

Communication system, communication device, communication adapter, communication method, and program

A controller in an energy management system is configured to acquire environmental parameters indicating an environment within a home. The controller is configured to receive a request from a terminal device installed outside the home for remotely operating a unit installed in the home such as an air-conditioning system. The controller is configured to transmit to the terminal device query data containing the acquired environmental parameters, and a query on whether to control the unit according to the request, when receiving the request. The controller is configured to control the unit based on a response to the query from the terminal device.

Controller, unit control system, unit control method, and non-transitory computer-readable recording medium

An acquirer acquires information concerning an energy management system for controlling a plurality of apparatuses installed in a dwelling. A display displays, in a first display region, the information acquired by the acquirer, and displays, in a second display region, a layout diagram in which images indicating the apparatuses are arranged at positions corresponding to installation locations of the apparatuses in the dwelling. Upon a determination that the information displayed in the first display region includes information concerning a specific apparatus among the plurality of apparatuses, the display displays with relative emphasis an image indicating the specific apparatus in the second display region.

Energy management system, terminal device, display control method, and program

A remote operation receiver () is configured to communicate with a communication terminal and receive a remote operation from outside a home. A remote operation monitor () is configured to monitor a state of communication with the communication terminal at the remote operation receiver () during an operation based on the remote operation. A notifier () is configured to provide in the home guidance to urge a user to conduct a manual operation on a manual operation receiver () when the remote operation monitor () detects that the communication with the communication terminal is discontinued. Then, an indoor device () is configured to make a shift to normal operation upon reception of the manual operation within a reference time period. An abnormal remote operation processor () is configured to set an extended time period corresponding to an operation state and then make a transition of the indoor device () to a safe operation when no manual operation is received even if the reference time period has elapsed.

Indoor device, home system, control method, and program

A control signal receiver of an equipment control device receives a control signal for equipment transmitted by a remote control terminal from a communication device via the Internet. A remote control authorization receiver receives, from a resident of a home, an authorization with respect to the control signal received by the control signal receiver. When the authorization receiver receives an authorization from the resident of the home, an equipment controller controls the equipment on the basis of the received control signal.

Equipment control device, equipment control method, and program

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Tokyo, Japan

Masayuki Komatsu