Kowa Company Limited

Kabushiki Kaisha Toyota Chuo Kenkyusho

Masayuki Kanishi

Hirofumi Takeuchi

Toshio Inagi

Makoto Kanebako

Hiroshi Miura

Yoshiaki Fukushima

Haruo Takahashi

Tsutomu Kajino

Yasuo Shinoda

A composition containing an extremely poorly water-soluble drug and obtained by treating, with a supercritical fluid or subcritical fluid of carbon dioxide, a mixture comprising a porous silica material and the extremely poorly water-soluble drug; and its production process. The porous silica material has an average pore diameter in a range of from 1 to 20 nm, pores having diameters within &#xb1;40% of the average pore size account for at least 60% of a total pore volume of the porous silica material, and in X-ray diffractometry, the porous silica material has at least one peak at a position of diffraction angle (2&#x3b8;) corresponding to a d value of at least 1 nm. The composition according to the present invention, which contains the extremely poorly water-soluble drug, is excellent in the dissolution of the extremely poorly water-soluble drug.

Composition containing medicine extremely slightly soluble in water being excellent in eluting property and method for preparation thereof

A composition containing a very low water-soluble drug, which composition is produced by treating, with a supercritical or subcritical carbon dioxide fluid, a mixture containing a very low water-soluble drug and a porous material (exclusive of a porous silica material characterized in that the material has an average pore diameter of 1 to 20 nm, the total pore volume of the material that have a diameter falling within a range of &#xb1;40% of the average pore diameter account for 60% or more the volume of all the pores of the material, and, when subjected to X-ray diffractometry, the material exhibits one or more peaks at a diffraction angle (2&#x3b8;) corresponding to d of 1 nm or more); and a method for producing the composition. The very-low-water-soluble-drug-containing composition of the present invention ensures improved dissolution of the very low water-soluble drug.

Composition containing medicine extremely slightly soluble in water and method for preparation thereof

Growing community of inventors

Numadu, Japan

Masayuki Kanishi