Asahi Kasei Chemicals Corporation

Masayuki Kakizawa

Mitsuo Yamashita

Kazuhiro Obae

Shinji Matsui

Shunichi Gomi

Hidetoshi Tomiyama

Yuichi Ozeki

This cellulose powder has: an average degree of polymerization of 100 to 350; a weight average particle size of over 30 &#x3bc;m, but less than 250 &#x3bc;m; an apparent specific volume of 2 to less than 15 cm/g; and an organic carbon content from residual impurities, which is defined by the total organic carbon content (%) during 1% NaOH extraction to the total organic carbon content (%) during pure water extraction, of over 0.07 to 0.3%.

Cellulose powder

This cellulose powder has: an average degree of polymerization of 100 to 350; a weight average particle size of over 30 &#x3bc;m, but less than 250 &#x3bc;m; an apparent specific volume of 2 to less than 15 cm/g; and a particle size distribution sharpness of 1.5 to 2.9.

It is an object of the present invention to provide a fine core particle, which comprises a coating layer having a uniform thickness, and which can be used to produce, at a high yield, a small granule causing no sandy feeling in the oral cavity when the fine core particle is applied to a fine granule or an orally-disintegrating tablet. According to the present invention, there is provided a core particle, which comprises 50% by mass or more of microcrystalline cellulose, and which has a mean particle diameter of less than 100 &#x3bc;m, a relative flow index of 7.0 to 30.0, a specific surface area of less than 0.15 m/g, and a tapped bulk density of 0.80 g/mL or more.

Cellulose-based fine core particle and process for producing the same

A process for producing a tablet characterized by performing high-speed direct compression with a moving speed of a pestle of 800 mm/s or more while compressing a powder which contains at least 15 to 80% by mass of cellulose, an active ingredient and a lubricant and has an angle of repose of 50&#xb0; C. or less, a compression degree of 20% or more and an elongation at break of 30 &#x3bc;m or more.

Growing community of inventors

Tokyo, Japan

Masayuki Kakizawa