Daiichi Sankyo Company, Limited

Hitachi-Kokusai Electric Inc.

Masayuki Ishizaki

Rie Miyauchi

Masatoshi Nagamochi

Shin Iimura

Sunanda Ghosh Dastidar

Ashwani Kumar Verma

Punit Kumar Srivastava

Kumaragurubaran Nagaswamy

Pradip Balu Wagh

Takeshi Murata

Yogesh Balasaheb Khairnar

Pramod Raosaheb Markad

Sonali Nanasaheb Pansare

Rijwan Jaffer Momin

Aniruddha Mondal

Balkrishna Ramchandra Kale

Soma Ghosh

Lalima Sharma

Hiroyuki Kobayashi

Hideaki Watanabe

Masami Arai

Teiji Wada

Toshifumi Tsuda

Kyoko Hara

Toshiki Tabuchi

Desired is development of novel CDN derivatives having STING agonist activity; and a therapeutic agents and/or therapeutic methods using the novel CDN derivatives for diseases associated with STING agonist activity. Further desired is development of a therapeutic agents and/or therapeutic methods capable of delivering the novel CDN derivatives specifically to targeted cells and organs for diseases associated with STING agonist activity. The present invention provides novel CDN derivatives having potent STING agonist activity, and antibody-CDN derivative conjugates including the novel CDN derivatives.

Cyclic dinucleotide derivative based antibody-drug conjugates

A wireless sensor network system includes: sensor terminals and a management terminal. A sensor terminal sends a join request at a first transmission power; and the management terminal calculates the traffic load of nodes on the reception path of the join request. If the number of hops and the traffic load are both within respective permissible ranges, the management terminal sets the reception path as the communication route of the sensor terminal. If the number of hops and/or the load is not within the permissible rage, the management terminal reconstructs the communication path by outputting an instruction to the sensor terminal to make direct connection to the management terminal or a specified node with a low traffic load, at a second transmission power greater than the first transmission power. When receiving the instruction, the sensor terminal transmits to the management terminal or the specified node at the second transmission power.

Wireless sensor network system

The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A' B, D, R, Rand Rare as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.

Heterocyclic compounds as protein kinase inhibitors

Growing community of inventors

Tokyo, Japan

Masayuki Ishizaki