Toyo Jozo Kabushiki Kaisha

Toyo Jozo Company, Ltd.

Masayuki Hori

Toshiharu Noda

Kaoru Morita

Toyonobu Uzawa

Nobutaka Fujii

A compound of the formula ##STR1## wherein Y is sulfur or methylene and A is Asn or Asp, or a pharmaceutically acceptable salt thereof is useful for the treatment of calcium metabolic disorders, cardiac disease and ulcers, and for the improvement of cranial circulation.

Calcitonin gene related peptide derivatives

A compound of the formula ##STR1## wherein R is H or H-Ala-NH- and when A is Asp, B is Asp or Glu, C is Leu and D is Val; when A is Asn and B is Gly, C is Phe and D is Gly; when A is Asn, B is Asp or Glu and C is Leu, D is Gly; and when A is Asn, B is Asp or Glu, and C is Phe, D is Val, or a pharmaceutically acceptable salt thereof, is useful for the treatment of calcium metabolic disorders, cardiac disease and ulcers, and for the improvement of cerebral circulation.

Calcitonin-gene-related peptide derivatives

A peptide represented by the following formula: ##STR1## wherein Y means a sulfur atom or methylene group, A stands for Asp or Asn, B denotes Val or Met and C is Asn or Ser, or a salt thereof.

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Shizuoka, Japan

Masayuki Hori