Tanabe Seiyaku Company, Limited

Terumo Kabushiki Kaisha

Masayoshi Samejima

Goichi Hirata

Kazuo Noda

Yoshiyuki Koida

Hiroyuki Yoshino

Yoshiyuki Hirakawa

Masao Kobayashi

Akira Kida

Toshio Wakabayashi

Takashi Ishibashi

Saburo Matsuda

Takashi Osawa

Shigeyuki Ishikawa

Naoki Hayakawa

Yoshinori Kobayashi

Disclosed is a controlled release pharmaceutical preparation, comprising a core containing a pharmaceutically active ingredient, and a porous film of a hydrophobic polymeric substance or a hydrophobic polymeric substance and a hydrophilic polymeric substance, the core being coated with the porous film. Disclosed is also a method for producing the same. The controlled release pharmaceutical preparation of this invention posseses a desired dissolution rate by controlling the porosity of the porous film.

Controlled release pharmaceutical preparation and method for producing

A process for micronizing a slightly-soluble drug characterized by subjecting a mixture of said drug and a sugar or sugar alcohol to high-speed stirring comminution or impact comminution in order to produce a micronized drug having an average diameter of less than about 2-3 mm. Also provided is a pharmaceutical formulation which comprises the micronized drug.

Process for micronizing slightly-soluble drug

A controlled release dosage form which consists essentially of a core containing a medicament; an inner coating layer composed of ethylcellulose and a hydrophobic substance; and an outer coating layer containing a medicament are disclosed. Said dosage form shows rapid increase in blood concentration of the medicament and at the same time maintains the high level of the blood concentration over a prolonged period time.

Controlled release dosage form

A parenteral alimentation solution having excellent nutritional properties with preventing problems such as browning which comprises three components of a reducing sugar, amino acids and electrolytes in a specific composition and a specific amount.

Parenteral alimentation solution

A process for preparing free-flowing microcapsules by taking advantage of the phase-separation of ethylcellulose in cyclohexane is disclosed. In this process, a hydrocarbon compound which is soluble in cyclohexane and have a molecular weight of 150 to 3,000 and a solubility parameter (.delta., at 25.degree. C.) of 7 to 10 (cal/cm.sup.3).sup.1/2 is used as the phase-separation-inducing agent.

Process for preparing free-flowing ethylcellulose microcapsules

Pharmaceutically active compound-containing microcapsules the coating walls of which consist essentially of ethylcellulose and a water-insoluble, acid-soluble polymer material are disclosed. A method of preparing said microcapsules is also disclosed.

Process for preparing ethylcellulose microcapsules

Ethylcellulose microcapsules, wherein a polymer material which shows at least 1.2 times increase in weight by immersing it in water at 37.degree. C. is incorporated into the ethylcellulose coating walls and/or the core material thereof, are disclosed. Said ethylcellulose microcapsules show rapid release of the core material in digestive organs such as stomach.

Microcapsules and method of preparing same

Microcapsules are prepared by conducting the phase-separation of a coating polymer material in the presence of ethylcellulose. Ethylcellulose present in the phase separation system minimizes the coagulation of the coating polymer material.

Method of preparing microcapsules

A process for preparing ethylcellulose microcapsules by flocculation of the ethylcellulose is disclosed. In this process, the flocculation of the ethylcellulose is carried out in the presence of an organosilicon polymer or in the presence of said organosilicon polymer and a surfactant.

A process for preparing ethylcellulose microcapsules of a pharmaceutically active compound by phase separation-coacervation of the ethylcellulose is disclosed. In this process, phospholipids are used as a phase-separation-inducing agent.

Process for preparing pharmaceutically active compound-containing

A process for the preparation of pharmaceutical substance-containing microcapsules by liquid-liquid phase separation is disclosed. In this process, ethyl cellulose having an ethoxy content of about 48 to about 49.5% by weight is used as a wall-forming agent and polyisobutylene is used as a phase separation inducing agent, and both or either one of the ethyl cellulose and polyisobutylene are used in the form of a mixture of two kinds differing in the average molecular weight.

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Minoh, Japan

Masayoshi Samejima