Ube Industries, Inc.

Chugai Seiyaku Kabushiki Kaisha

Masayoshi Oku

Kikuo Ataka

Shoji Shikita

Tadashi Murakami

Hiroyuki Miyata

Yasuhisa Fukuda

Katsuhiko Mizutare

Akira Takama

Tatsuya Kawaguchi

Kazuma Sakata

Hiroyuki Ota

Masanori Sone

Hiroyuki Suenaga

Tsuyoshi Ueyama

The present invention is to provide a process for preparing a 3-unsubstituted-5-amino-4-nitrosopyrazole compound represented by the formula (1):  

Process for producing 3-unsubstituted 5-amino-4-nitrosopyrazole compound, and 2-hydroxyimino-3-oxopropionitrile, 3-hydrazono-2-hydroxyiminopropionitrile compound, and processes for producing these

The present invention is to provide a process for producing a 2'-O-acetyl-4&#x2033;-formyl-8,9-anhydroerythromycin A 6,9-hemiketal compound 4, and it provide a process for producing an erythromycin compound which comprises reacting a formylating agent with a 2&#x2032;-O-acetylerythromycin A compound 2 to obtain 2-&#x2032;-O-acetyl-4&#x2033;-O-formylerythromycin A compound 3, then, acting an acid on Compound 3 to subject to hemiketalation, and then adding an aqueous basic solution in an aqueous solution to precipitate Compound 4 as free crystals.

Process for preparing erythromycin compound

A pivaloylacetic acid ester is prepared at a high yield by decarbonylating a pivaloylpyruvic acid ester in gas or liquid phase in the presence of an inorganic oxide catalyst which comprises aluminum in an amount of 10% by weight or more in terms of aluminum oxide, and preferably is substantially free from heavy metals, for example, Fe, Cu, Ni, Mn, Cr, Mo and Co, and exhibits a high catalytic activity and chemical stability.

Method of producing pivaloylacetic acid ester

There are disclosed 2,4,5-Trifluoro-3-hydroxybenzoic acid represented by the following formula (I): ##STR1## and a salt thereof and a process for preparing the same. Further, there is disclosed a process for preparing 3,5,6-trifluoro-4-hydroxyphthalic acid, which is employed for preparing the above compound.

Trifluorohydroxyaromatic acid and preparation thereof

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Ube, Japan

Masayoshi Oku