Eisai R&d Management Co., Ltd.

Eisai Company, Limited

Masayoshi Ohkuro

Tetsuya Kawahara

Naoki Yoneda

Makoto Kotake

Shinsuke Hirota

Toshihiko Kaneko

Kenzo Muramoto

Fumihiro Ozaki

Richard S Clark

Kazuo Okano

Atsushi Kamada

Norihito Ohi

Hiromitsu Yokohama

Tohru Arai

Osamu Takenaka

Jiro Sonoda

In one aspect, the present invention provides compounds having formula (1) or (100), a salt thereof or a hydrate of the foregoing, which compounds exhibit excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and are useful as therapeutic or prophylactic agents for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome; rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis.  wherein R10 represents optionally substituted cycloalkyl, etc., R20-23 represent hydrogen, alkyl, alkoxy, etc., R30-32 represent hydrogen, alkyl, oxo, etc., and R40 represents optionally substituted alkyl, etc.

1,2-di(cyclic)substituted benzene compounds

A compound represented by the following general formula (1) or (100), a salt thereof or a hydrate of the foregoing has excellent cell adhesion inhibitory action or cell infiltration inhibitory action, and is useful as a therapeutic or prophylactic agent for various inflammatory diseases and autoimmune diseases associated with adhesion and infiltration of leukocytes, such as inflammatory bowel disease (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. 

Benzopiperidine derivatives

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Tsukuba, Japan

Masayoshi Ohkuro