The Institute of Physical and Chemical Research

Masayoshi Nakasako

Isao Endo

Masafumi Odaka

Masafumi Yohda

Koji Takio

Disclosed are peptides represented by IVC SLC SC TAW and C SLC SC wherein I stands for isoleucine, V for valine, C for cysteine, C for cysteinesulfinic acid, C for cysteinesulfenic acid, S for serine, L for leucine, T for threonine, A for alanine, and W for tryptophan. These peptides can impart photoreactivity to a protein by binding to a non-heme iron. Also disclosed are methods for imparting photoreactivity to cells by introducing the peptide sequences into at least one protein which is involved in a metabolic system and/or energy metabolic system of the cells. There can be provided peptide sequences with a shorter peptide chain capable of imparting photoreactivity, which can be easily introduced into a protein with a little risk in degrading original function of the protein. There are also provided methods enabling control of metabolic reactions by imparting photoreactivity to cells with the peptides.

Undecapeptides containing cysteinesulfinic and cysteinesulfenic acid

Disclosed are peptides represented by IVC,SLC,SC,TAW and C,SLC,SC,wherein I stands for isoleucine, V for valine, C,for cysteine, C,for cysteinesulfinic acid, C,for cysteinesulfenic acid, S for serine, L for leucine, T for threonine, A for alanine, and W for tryptophan. These peptides can impart photoreactivity to a protein by binding to a non-heme iron. Also disclosed are methods for imparting photoreactivity to cells by introducing the peptide sequences into at least one protein which is involved in a metabolic system and/or energy metabolic system of the cells. There can be provided peptide sequences with a shorter peptide chain capable of imparting photoreactivity, which can be easily introduced into a protein with a little risk in degrading original function of the protein. There are also provided methods enabling control of metabolic reactions by imparting photoreactivity to cells with the peptides.

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Wako, Japan

Masayoshi Nakasako