Ono Pharmaceutical Co., Ltd.

Other

Tasuku Honjo

Ono Pharmaceuticalco.,ltd.

Honjo, Tasuku

Masayoshi Matsuo

Shiro Shibayama

Takao Yoshida

Masakazu Miyamoto

Kazuhiko Takeda

Akio Hayashi

The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein on cell membrane of human PD-1-expressing cells and can transmit inhibitory signal of human PD-1, it is useful for therapy and/or prevention of diseases caused by immunopathy.

Substance specific to human PD-1

Compounds that can recognize selectively both PD-1 protein and a membrane protein co-existing with PD-1 on a cell membrane, and can transmit a suppressive signal of PD-1. The compounds are useful for medical treatment and/or prevention of diseases caused by immune abnormality.

Substance that specifically recognizes PD-1

Peptides, method for assaying human pepsinogen II or human pepsin II, and assaying kit

Peptides, methods for assaying human pepsinogen I or human pepsin I and assay kits

Growing community of inventors

Osaka, Japan

Masayoshi Matsuo