Hoechst Japan Limited

Masayoshi Koyama

Mikiko Takahashi

Kazuyuki Doi

Masayoshi Yanagawa

Pharmaceutical composition for preventing or treating bone fracture comprising as an active ingredient a platelet factor 4. The present composition can promote differentiation of osteoblasts so that they are effective for prophylaxis and treatment of such diseases requiring bone differentiation and proliferation as bone fracture and the like.

Medicine for preventing and curing bone fracture

L-lysyl-glycyl-histidine and metal complexes thereof, for example, L-lysyl-glycyl-L-histidine: copper (II). The L-lysyl-glycyl-L-histidine and salt thereof have a fibroblast proliferation promoting activity and then it is useful as a wound healing agent.

L-lysyl-glycyl-L-histidine and therapeutic agent for wound healing

A protein named PHBP-70 having a wound-healing activity which has a molecular weight of about 60-80 KDa by analysis with SDS-PAGE under reducing conditions and can be obtained from the blood of the fetus and neonates of mammals including human beings. The protein PHBP-70 is a novel protein having a fibroblast proliferating activity and thus it is useful as a wound-healing agent.

Growing community of inventors

Saitama, Japan

Masayoshi Koyama