Eisai Company, Limited

Sansho Co., Ltd.

Takasago International Corporation

Masayoshi Kasai

Masanori Kayano

Mitsuhiro Yoshida

Hiroyuki Fujimori

Akira Sasaki

Yoshifumi Yuasa

Yoshio Ishino

Toyohiko Kobayashi

Shigeru Sakashita

Shigemitsu Osawa

Keizo Uesugi

Shigeru Aoki

Keiji Ohmori

Noriko Konita

Hidenori Asakawa

Toshio Kurobe

Preparation for endermism containing dopamine derivatives

A pharmaceutical composition comprises (a) a pharmacologically effective amount of bunazosin or a pharmacologically acceptable salt thereof and (b) a monoglyceride of a fatty acid having 8 to 12 carbon atoms and/or a lactic acid ester of an aliphatic alcohol having 12 to 18 carbon atoms and is improved in percutaneous administration. ##STR1##

Pharmaceutical preparation for percutaneous administration containing

A multi-layered granule comprises an inner, slow-releasing layer, an outer, rapid-releasing layer and an intermediate layer provided between said slow-releasing layer and said rapid-releasing layer which intermediate layer comprises a hardened oil and hydroxypropyl cellulose or methyl cellulose.

Multi-layer granule

An effervescent vaginal suppository composition containing a stabilizer appropriately selected from the group consisting of anhydrous sodium sulfate, anhydrous silica gel, dried magnesium silicate, dried aluminum silicate, dried calcium carboxymethylcellulose, dried microcrystalline cellulose, dried starch and dried calcium phosphate or mixtures thereof, preferably in an amount of 0.1-20% based on the weight of said effervescent vaginal suppository composition. Shaped effervescent vaginal suppositories are produced therefrom.

Stable, effervescent vaginal suppositories

Growing community of inventors

Gifu, Japan

Masayoshi Kasai