Mect Corporation

Kanto Ishi Pharmaceutical Co., Ltd.

Rikagaku Kenkyusho

Sony Corporation

Mitsui Toatsu Chemicals, Incorporated

Mitsubishi Denki Kabushiki Kaisha

Masayoshi Ito

Yoshiyasu Shitori

Tomoya Ogawa

Shoji Yoshimura

Mamoru Sugimoto

Masaaki Numata

Haruo Ogura

Kimio Furuhata

Shohei Shibayama

Yoshitaka Nagai

Yuzi Matsuzaki

Toshiaki Osawa

Kinji Takada

Satoshi Toyoshima

Shingo Sato

Sadanori Ogasawara

Atsushi Okamura

Akira Awaya

Koji Inoue

Toshio Wakayama

Masashi Mitsumoto

Takashi Sekiguchi

Kenji Iwata

Makoto Tanaka

Takayuki Inaba

Hisashi Kobayashi

Hayao Abe

Yusaku Ishizuka

Isao Suda

Shuji Fujita

Hideki Yamamoto

Kenji Abiko

Shigeki Nunomura

Yoshinori Yamano

Tetsura Utsumi

Masahiko Mitsuzuka

Katsuhide Kariya

Takashi Hanafusa

Tatsurou Sakamoto

Youzi Matsuzaki

Yoichiro Tani

Atsushi Kawamura

A radar device separates directions of a plurality of targets, obtained from combinations of antenna beams, with a high accuracy. The radar device includes: a direction calculating unit for calculating a primary direction, which is the direction of a target, from a combination of characterizing quantities calculated by a signal detector from the reception waves of at least two beams that partially overlap, among the beams radiated in the plurality of directions; and a direction integrating unit for, when a plurality of primary directions calculated by the direction calculating unit is present, calculating an integrated direction, which is the true target direction, from an area in which distribution of the plurality of primary directions is a predetermined density or greater, based on the primary directions belonging to the area.

Radar device

A method for preparing a highly heat-resistant and burning-resistant poly(silyleneethynylene phenyleneethynylene) having a repeated unit represented by the following structural formula (1A): ##STR1## wherein the phenylene group may be in the o-, m- or p-form, R represents a halogen atom or an alkyl group, alkoxy group, phenoxy group, alkenyl group, alkynyl group, aromatic group, disubstituted amino group or silanyl group; n is an integer ranging from 0 to 4; and R' represents a hydrogen atom, an alkyl group, alkenyl group, alkynyl group or aromatic group, a product obtained by the method and a hardened product obtained by heat-treating, at a temperature ranging from 50.degree.to 700.degree. C., the poly(silyleneethynylene phenyleneethynylene).

Poly(silyleneethynylene phenyleneethynylenes), method for preparing same

A speaker cabinet in which a cross section of an outer peripheral portion (11) is formed as an elliptic shape and opening portions (22 to 25) formed on the outer peripheral portion (11) and into which speakers (2 to 5) are mounted are formed as horn shapes whose diameters are improved toward the outside. The speaker cabinet includes a plywood member (10) that is formed by laminating a hard plate member, a soft plate member and a light and soft rear surface plate member on a face front surface plate member. The cabinet is molded in a predetermined curved fashion to have an elliptic shape. Thus, an acoustic characteristic of the speaker cabinet can be increased and a manufacturing cost of the speaker cabinet can be reduced.

Speaker cabinet

A hybridoma producing a monoclonal antibody specific for free N-acetylneuraminic acid or beta glycoconjugates thereof, is herein disclosed. The hybridoma can be generated by fusing (i) B cells of lymphocytes obtained by immunizing an animal with an N-acetylneuraminic acid or a beta-glycoconjugate thereof, and (ii) myeloma cells.

Monoclonal antibodies specific for free N-acetylfuraminic acid and

A monoclonal antibody specifically recognizes an epitope or an antigenic determinant represented by the following formula and specifically reacts therewith: ##STR1## The monoclonal antibody can be obtained by cultivating hybridoma cells which can be generated by a method comprising cell-fusing (A) B cells or lymphocytes obtained by immunizing an animal with a substance involving the epitope or the antigenic determinant represented by the foregoing formula and (B) myeloma cells. The monoclonal antibody shows high specificity to ganglioside GQ.sub.1b and ganglioside GT.sub.1a having a specific epitope and thus can detect the epitope in high sensitivity. Therefore, the antibody can be used for the elucidation of sugar chain's roles in cell functions and for studying the development of animals. Moreover, the monoclonal antibody would have various clinical applications.

Monoclonal antibodies capable of recognizing gangliosides GQ.sub.1b and

The present invention relates to a sodium salt of sialosyl cholesterol. The present compound has an excellent high water solubility, and therefore the compound is very useful as a medicine to be used for treating various diseases derived from lesions of peripheral or central nerves.

Sialosyl cholesterol and neuropathy remedy comprising the same

The present invention relates to ganglioside related compounds having, for example, the following formula: ##STR1## where R.sub.1 represents H or COCH.sub.3 (hereinafter abbreviated to 'AC'); R.sub.2 represents H or CH.sub.3 ; and R.sub.3 represents --OH, ##STR2## These ganglioside related compounds are useful as membrane receptors, tumor markers, cell growth controlling substances, etc., and useful for immunotherapy for cancer, etc.

Ganglioside related compounds and method of producing the same

Sialocylglycerolipids represented by the following general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a group CH.sub.3 CO--; R.sup.2 represents an alkali metal, a hydrogen atom or a lower alkyl group; R.sup.3 represents a hydrogen atom or a group C.sub.n H.sub.2n+1 -- (n is an integer ranging from 1 to 30); and R.sup.4 represents a group C.sub.m H.sub.2n+1 -- (m is an integer ranging from 1 to 30) are herein disclosed. They are prepared by treating a corresponding compound in an alkaline aqueous solvent. The method makes it possible to provide these compounds in a high yield by a simple processes.

Sialocylglycerolipids and method for preparing the same

Sialosyl cholesterol, process for producing the same, and neuropathy

A repairing agent for cells and tissues is disclosed, which agent comprises, as an active ingredient, a compound of the general formula: ##STR1## wherein Z represents lithium, potassium, sodium, ammonium or an organic ammonium when n is 1, and Z represents calcium, barium or magnesium when n is 2.

Repairing agent for cells and tissues

The present invention relates to sialic acid derivatives. According to the present invention, there is provided sialic acid derivatives having the general formula (I): ##STR1## wherein, R.sup.1 represents hydrogen, an acetyl group, a trityl group, ##STR2## (R.sup.5 represents hydrogen or an acetyl group and R.sup.6 represents hydrogen, sodium or a methyl group). R.sup.2 represents hydrogen or an acetyl group,

Sialic acid derivatives and process therefor

Novel sialic acid derivatives and galactose derivatives which are useful intermediate for the synthesis of gangliosides. Methods for the production of the sialic acid and galactose derivatives. Methods for the production of ganglioside GM.sub.3.

Sialic acid derivatives, galactose derivatives and method for producing

A sialic acid-bonded octapeptide represented by the following general formula (I): ##STR1## wherein R represents a hydrogen atom or an acetyl group; and R' represents a lower alkyl group, an aralkyl group, a hydrogen atom or an alkali metal atom, is herein disclosed. The peptide chain of the sialic acid-bonded octapeptide is constituted by 8 amino acid molecules on the C-terminus side of FTS and the compounds represented by formula (I) can be obtained by bonding sialic acid to the amino terminus of the peptide chain according to condensation. These octapeptides show excellent physiological activity comparable to FTS and a half life in blood longer than that of FTS and it is expected that the affinity of the peptide to lymphocytes is also enhanced. Thus they can effectively be used as medicines for treating the lowering and abnormality of functions of the thymus.

Sialic acid-bonded octapeptide and preparation thereof

The present invention provides ganglioside-related compounds expressed by the following formula: ##STR1## (wherein R.sub.1 denotes a hydrogen atom or SiR.sub.3 R.sub.4 R.sub.5 (wherein R.sub.3 and R.sub.4 each denotes a methyl or phenyl group, and R.sub.5 denotes a tertiary butyl or dimethylphenylmethyl group), and R.sub.2 denotes a hydrogen atom, a trityl group, or ##STR2## (wherein M denotes an alkali metal atom)) and methods of producing the same. These ganglioside-related compounds are useful as markers for the early detection of cancer and in the immunotherapy for cancer.

Glycolipid containing N-glycolylneuraminic acid and method of producing

The present application discloses a new sialosyl glyceride having the following formula, which compound is useful as a remedy for nervous diseases, has an excellent compatability with the living bodies, and is easily producible. ##STR1## wherein R.sup.1 represents a hydrogen atom or XCH.sub.2 CO-- (X being a halogen atom), R.sup.2 represents an alkali metal, a hydrogen atom or a lower alkyl group, R.sup.3 represents a hydrogen atom or --CO(CH.sub.2)mCH.sub.3, R.sup.4 represents --CO(CH.sub.2)mCH.sub.3 amd m and n each represents a number of 0 to 30.

Sialosyl glyceride and process for producing the same

Growing community of inventors

Kunitachi, Japan

Masayoshi Ito