Kumamoto University

Chisso Corporation

Jnc Corporation

Nagase Chemtex Corporation

National University Corporation Kumamoto

Masayo Sakata

Masami Todokoro

Chuichi Hirayama

Minoru Nakayama

Daisuke Nakamura

Yuki Maeda

Masashi Kunitake

Towako Sakamoto

Means for removing endotoxin is provided. Endotoxin is removed by contacting an endotoxin adsorbent including a cellulose nanofiber having an amino group with a liquid containing endotoxin.

Endotoxin adsorbent

A means for selectively removing ET under coexistence of a substance showing a negative charge, such as nucleic acid is described. Endotoxin is selectively removed by bringing a polymer obtained by crosslinking cyclodextrin with an isocyanate-based crosslinking agent in contact with a solution containing endotoxin and the substance showing the negative charge such as nucleic acid.

A nucleic acid adsorbent in which a polymer having a constitutional unit represented by the following formula (I) is immobilized on a water-insoluble carrier is used as a nucleic acid adsorbent capable of selectively and efficiently adsorbing nucleic acids from complex mixtures, such as cell extract, 

Nucleic acid adsorbent; methods for adsorbing, removing, dissociating, and recovering nucleic acids using the same; and method for regenerating the same

This invention provides an adsorbent having a high ability to adsorb endotoxin selectively and a method of adsorbing endotoxin. The adsorbent comprises a basic substance bonded to a base material by means of a crosslinking agent.

Endotoxin adsorbent, and a method of removing endotoxin by using the same

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Kumamoto, Japan

Masayo Sakata