Basf Se Corporation

Meiji Seika Kaisha, Ltd.

Meiji Seika Pharma Co., Ltd.

Masayo Sakai

Kazumi Yamamoto

Takashi Ando

Masaaki Mitomi

Kimihiko Goto

Ryo Horikoshi

Kazuhiko Oyama

Ando Takashi

A process for producing compound C represented by formula C is disclosed: wherein R' represents substituent groups as described herein. The process can produce pyripyropene derivatives that have acyloxy groups at the 1- and 11-positions and a hydroxyl group at the 7-position and are useful as insect pest control agents at a high yield.

Process for producing pyripyropene derivatives and intermediates for the production thereof

Disclosed is a process for producing compound C represented by formula C: wherein R' represents straight chain, branched chain, or cyclic Calkylcarbonyl, wherein Ris used as a protective group for hydroxyl at the 7-position of compound C. Rrepresents formyl; optionally substituted straight chain Calkylcarbonyl; optionally substituted benzyl; group &#x2014;SiRRRoptionally substituted by halogen atom wherein R, R, and Reach independently represent straight chain or branched chain Calkyl or phenyl; Calkyloxy-Calkyl optionally substituted by halogen atom; Calkylthio-Calkyl optionally substituted by halogen atom; straight chain, branched chain, or cyclic Calkyl optionally substituted by halogen atom, provided that, when alkyl in the Calkyl group is of a branched chain or cyclic type, the alkyl group is Calkyl; Calkenyl optionally substituted by halogen atom; Calkynyl optionally substituted by halogen atom; or an optionally substituted saturated or unsaturated five- or six-membered heterocyclic group. The process can produce pyripyropene derivatives that have acyloxy groups at the 1- and 11-positions and a hydroxyl group at the 7-position and are useful as insect pest control agents at a high yield.

An objective of the present invention is to provide an ectoparasite control agent for homothermic animals, which has high control effect and is safe. The compounds according to the present invention are compounds represented by formula (I) and salts thereof:wherein Rrepresents optionally substituted alkyl; optionally substituted alkenyl; optionally substituted alkynyl; ORwherein Rrepresents optionally substituted alkyl, optionally substituted alkenyl, or optionally substituted alkynyl; or SRwherein Ris as defined above, Rrepresents optionally substituted alkyl, any one of Rand Rrepresents hydrogen and the other represents fluorine, chlorine, bromine, or CF, and X represents fluorine or chlorine.

Halogen-substituted quinoline derivatives and ectoparasite control agent

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Yokohama, Japan

Masayo Sakai