The University of Tokyo

Masayo Sakabe

Tetsuo Nagano

Yasuteru Urano

Mako Kamiya

Norihiro Kokudo

Takeaki Ishizawa

Suguru Yamashita

Methods for identifying the presence of cancerous cells or tissue by: applying a compound of formula (I), or salts thereof, to a living body, wherein Rrepresents hydrogen or the same or different one to four substituents; R, R, R, R, R, and Rindependently represent hydrogen, hydroxy, alkyl, or halogen; Rand Rindependently represent hydrogen or alkyl; and X represents C-Calkylene; and detecting fluorescence emitted by a compound of formula (II), wherein R, R, R, R, R, R, R, R, and Rare as defined above; wherein fluorescence emitted by a compound of formula (II) is indicative of the presence of cancerous cells or tissue.

Method for diagnosing cancer

A fluorescent probe for detecting pancreatic fluid containing a compound or salt thereof represented by formula (I) below. (In the formula, A represents an amino acid residue or N-substituted amino acid residue, with A forming an amide bond with the adjacent NH in the formula; Rrepresents a hydrogen atom or 1 to 4 same or different substituent groups that bond with a benzene ring; R, R, R, R, R, and Reach independently represent a hydrogen atom, a hydroxyl group, an alkyl group, or a halogen atom; Rand Reach independently represent a hydrogen atom or an alkyl group; and X represents a C-Calkylene group).

Fluorescent probe for high-sensitivity pancreatic fluid detection, and method for detecting pancreatic fluid

A compound represented by the formula (I) or a salt thereof (Rrepresents hydrogen atom, or a substituent; Rto Rrepresent hydrogen atom, hydroxyl group, an alkyl group, or a halogen atom; Rand Rrepresent hydrogen atom, or an alkyl group; X represents a C-Calkylene group; and Rrepresents an acyl group), which promptly causes a structural change from a non-fluorescent closed ring structure to a strongly fluorescent open ring structure by hydrolysis of an acyl group, and is useful as a fluorescent probe for measuring a protease showing superior suitability for quantification. 

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Tokyo, Japan

Masayo Sakabe