Teijin Limited

Masayasu Tabe

Atsuo Hazato

Kenji Manabe

Hiroko Tanaka

Qingzhi Gao

Seiichi Ishizuka

Toru Minoshima

Minoru Furuya

Osami Takenouchi

Yoshiaki Azuma

Koji Tomimori

Yasuji Sakuma

Hiroaki Mitsuhashi

Qinqzhi Gao

Tadashi Kishimoto

Manabu Chokki

A 5-(3-cyanophenyl)-3-formylbenzoic acid compound of the formula (IV) is prepared by reacting a 5-bromo-3-(hydroxymethyl)benzoic acid compound of the formula (I) with manganese dioxide to provide a 5-bromo-3-formylbenzoic acid compound of the formula (II), and then reacting the resultant compound of the formula (II) with 3-cyanophenylboronic acid of the formula (III) in the presence of a palladium complex.R is a H atom or a C-Calkyl group.

Process for producing 5-(3-cyanophenyl)-3-formylbenzoic acid compound

The starting materials for a production process of a vitamin D,derivative are disclosed, e.g., a cyclopentene derivative represented by the formula (1-2):

Vitamin D3 derivative and production process thereof

Vitamin D.sub.3 derivative and treating agent for inflammatory

A vitamin D.sub.3 derivative represented by the following formula: wherein, R is, independently, a hydrogen atom, tri(C.sub.1 to C.sub.7 hydrocarbon)silyl group, C.sub.2 to C.sub.8 acyl group, or group forming an acetal bond together with an oxygen atom of a hydroxyl group, A is ##STR1## where, R.sup.1 is a methyl group or methylene group, and when R.sup.1 is a methylene group, the bond between the R.sup.1 and the 3-position of the lactone ring is a double bond, R.sup.2 is a hydrogen atom or C.sub.1 to C.sub.3 alkyl group, R.sup.3 is a hydrogen atom, or R.sup.2 and R.sup.3 together indicate a substitutable single methylene group.

Vitamin D.sup.3 derivative and production process thereof

Vitamin D.sub.3 derivatives and production process thereof

A lactone compound, useful as an osteogenetic accelerator, having the formula (I): ##STR1## wherein n is zero or 1 and m is zero or 1, provided that both n and m are not zero at the same time, or a stereoisomer thereof at the 23- and/or 25-positions or any mixture thereof and a production process thereof.

Lactone compound and process of production thereof

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Hino, Japan

Masayasu Tabe