Koken Company, Limited

Shiseido Company, Limited

Sumitomo Pharmaceuticals Company Limited

Masayasu Furuse

Teruo Miyata

Yasuharu Noishiki

Kazuhiko Kodaira

Keiji Fujioka

Shigeji Sato

Yoshio Sasaki

Yoshimitsu Kuroyanagi

Tetsuro Namiki

Hiromi Naito

Takashi Suzuki

Taichiro Akiyama

Makoto Tsunenaga

Naoki Tominaga

Toshio Nishiyama

Hitoshi Koyanagi

Takeaki Miyamoto

Hiraku Ito

Toru Yamashita

Mutsumi Fukuyama

Eisaburo Imamura

A method for drying a wetted molded product of pasty high viscous composition which comprises subjecting the molded product to a dehydration process while wholly or partially contacting the product with an open-cell foamed hydrophobic porous membrane.

Method for drying wetted molded product

A hyaluronic acid-containing aqueous solution or aqueous dispersion of collagen having a pH of from about 6.5 to about 8.0 and an osmolality of from about 230 to about 320 mOsm/kgH.sub.2 O. The aqueous solution or the aqueous dispersion of collagen is useful as an agent for correction and reparation of a depressed part of or a void in soft tissue of mammals.

Hyaluronic acid-containing aqueous solution or aqueous dispersion of

A bioprosthetic valve made from a biological tissue containing collagen which has been cross-linked with a polyepoxy compound is disclosed. The valve has excellent biocompatibility and is durable and is free from calcification.

Bioprosthetic valve

A method for preparing a sustained release formulation utilizing collagen and/or gelatin as a carrier, which comprises the steps:

Method for producing sustained release formulation

This invention relates to a surfactant with less toxicity and irritation against the human body and a production process thereof. The surfactant is produced by the acylation of the side chain amino radicals of collagen or gelatine with an aliphatic acid having 2 to 26 carbon atoms; it is used as an emulsifier and an antiseptic for cosmetics.

Surfactant composed of acylated collagen or acylated gelatine and a

In a method of preparing an antithrombogenic medical material having a heparinized collagen as an antithrombogenic component, there is provided a method comprising the steps of fixing a protamine to a collagen through a polyepoxy compound, and heparinizing the collagen by fixing heparin to the protamine.

Method of preparing antithrombogenic medical materials

This invention relates to a hemostatic agent used in surgical operations, which can be produced in two ways: one blending collagen/gelatin with protamine, the other blending collagen/gelatin with protamine and a bi-functional cross-linking agent so as to make said collagen/gelatin have a covalent bond with said protamine. The produced hemostatic agent can stop bleeding within far less time than a conventional hemostatic agent made out of pure collagen.

Hemostatic agent composed of collagen/gelatin and protamine

This invention relates to a surfactant composed of acylated collagen or acylated gelatine produced by the acylation of the side chain amino radicals of collagen or gelatine with an aliphatic acid having 2-26 carbon atoms and a dicarboxylic acid having 2-8 carbon atoms and a production process thereof. Since it has less toxicity and irritation against the human body and can dissolve in a neutral solution of pH 6-8 in the form of molecular dispersion, the surfactant is especially suitable for use in the field of cosmetic and foodstuff industries.

This invention concerns a production process of an antithrombogenic and antiadhesive material which can favorably be used as artificial blood vessels, artificial valves, grafting patches for cardiovascular organs, artificial heart catheters and so on. The gist of this invention is constructed substantially of subjecting glycidyltrialkylammonium halide such as glycidyltrimethylammonium chloride to the reaction with a material comprising pure collagen or collagen and other components like mucopolysaccharide in order to introduce a cationic quaternary functional group in collagen molecules of the material and then subjecting heparin to the ionic combination with the cationic functional group introduced. Meanwhile, in advance of the above chemical treatment, the material is prepared from dog's blood vessel by removing proteins except collagen, from cow's Achilles tendon by crushing into powder, from human amnion by rinsing in distilled water or from polyester knit tube by coating its inside with powdered collagen, for example.

Production process of an antithrombogenic and antiadhesive material for

Artificial bone is prepared from animal bone treated for removal of organics, burned, baked and immersed in atelocollagen solution.

Growing community of inventors

Sagamihara, Japan

Masayasu Furuse