Keio University

Japan Science and Technology Agency

Osaka University

Namco Limited

Sumitomo Dainippon Pharma Co., Ltd.

Kringle Pharma Inc.

Sysmex Corporation

Kyoto University

National Cancer Center

Masaya Nakamura

Shinya Yamanaka

Hideyuki Okano

Yoshiaki Toyama

Toshikazu Nakamura

Akihiko Sano

Kiyoshi Ando

Yohei Okada

Yonehiro Kanemura

Tatsuji Nomura

Keigo Hanada

Akiyoshi Kishino

Akira Kawai

Kazutaka Kikuta

Hiroshi Funakoshi

Miho Maeda

Yoshikuni Tanioka

Liang Zhang

Akio Iwanami

Kazuya Kitamura

Tadashi Kondo

Osahiko Tsuji

Kyoko Miura

A method for differentiating a human differentiated cell-derived pluripotent stem cell into a neural stem cell is provided, which includes the steps of: making an embryoid body from the human differentiated cell-derived pluripotent stem cell; and culturing the embryoid body in a medium containing LIF to differentiate into a neural stem cell, so that, when the neural stem cell is allowed to differentiate in vitro after multiple subculturing of the neural stem cell, it differentiate mainly into neurons but substantially not into glial cells.

Culture method of embryoid bodies and/or neural stem cells derived from human differentiated cell-derived pluripotent stem cells

The present invention is a solid sustained-release formulation comprising an agent for inhibiting semaphorin 3A as an active ingredient, which comprises an agent for inhibiting semaphorin 3A and pharmaceutically acceptable hardly water-soluble solid substance, in which the carrier is silicone.

Preparation for treatment of spinal cord injury

Disclosed is a therapeutic agent effective for the fundamental treatment of a spinal cord injury and a demyelinating disease. Specifically disclosed are a therapeutic agent for a spinal cord injury and a therapeutic agent for a demyelinating disease, each of which comprises an HGF protein as an active ingredient.

Therapeutic agent for spinal cord injuries

A method for creating a monkey model of spinal cord injury, which includes exposing the dura mater of the cervical cord of a monkey and applying a load on the dura mater; the thus-created monkey model of spinal cord injury; and a method for evaluating a therapeutic drug for spinal cord injury by use of this model. According to the present invention, it is possible to create a monkey which is close to the human and thus useful as a model of human spinal cord injury. This model enables proper evaluation of therapeutic effects of various drugs on spinal cord injury. Through use of this model, it has been confirmed for the first time that transplantation therapy of human neural stem cells is efficacious against spinal cord injury.

Method of constructing spinal injury model monkey and utilization thereof

A game machine has a plurality of targets which unpredictably come out and disappear from their corresponding holes at the surface of a table on a game stand. A player can only strike targets which are positioned above the surface thereof. A main shaft is provided with the target on its upper end and is supported by bearings in such a manner that it can rotate and move up and down. A plunger disposed at the periphery of the main shaft is magnetically attracted by an electromagnetic solenoid. When raised, the main shaft always faces a predetermined direction due to an action of permanent magnets. Hitting of the target can be detected by monitoring abrupt large fluctuations in current flowing through the solenoid during a period of time that the target is caused to appear above the table.

Game machine having pop-up target

Growing community of inventors

Tokyo, Japan

Masaya Nakamura