Japan Science and Technology Agency

Teijin Limited

Hokkaido University

Research Development Corporation of Japan

Toyota Jidosha Kabushiki Kaisha

Fujifilm Corporation

Showa Denko K.k.

Tohoku University

Masatsugu Shimomura

Hiroshi Yabu

Takahiko Hariyama

Daisuke Ishii

Hiroshi Suzuki

Masaru Tanaka

Yoshinori Muranaka

Isao Ohta

Yasuharu Takaku

Hiroaki Kaneko

Yoshihiko Sumi

Yukako Fukuhira

Masafumi Takebayashi

Kunihara Ijiro

Ryuji Monden

Hiroshi Iwanaga

Masaya Ito

Ko Okumura

Yoshikazu Hosoda

Eiichi Kitazono

Tamami Koyama

Atsushi Suzuki

Kentaro Shiratsuchi

Takeshi Higuchi

Masashi Sakaguchi

Masataka Kaido

Koji Nakazawa

Yuji Hirai

Hideaki Kawasaki

Satoshi Hirakawa

Marie Tani

A combined-blade open flow path device is a fluid flow path device where flow paths are adjacent to each other. The combined-blade open flow path device comprises a substrate configured to constitute a bottom portion of the flow paths; and blades erected on a surface of the substrate, the blades being configured to constitute side walls of the flow paths, wherein the blades are erected in groups, each of the groups extending from an upstream side to a downstream side in a flow direction of a fluid with a space between each of the blades in the flow direction of the fluid in each of the groups for making conduction of the fluid between the adjacent flow paths possible, and wherein one end of one of the flow paths is configured to be in contact with the fluid and is configured to make a flow of the fluid possible.

Combined-blade open flow path device and joined body thereof

Provided are a protective agent for electron microscopic observation in a vacuum which can protect a biological sample in a water-containing state, such as a mammal, a plant tissue or a cultured cell, and a single cell in the living state without deforming it even in a vacuum, a kit using the same, methods for observation, diagnosis, evaluation, and quantification of a sample by an electron microscope, and a sample stage to be used for the observation. The protective agent for electron microscopic observation of the present invention contains a a component to impart the survival environment, a saccharide, and an electrolyte.

Protective agent for electron microscopic observation of biological sample in water-containing state, kit for electron microscopic observation, methods for observation, diagnosis, evaluation, and quantification by electron microscope, and sample stage

Provided is a technique for fabricating a novel thin membrane with a starting material such as a biocompatible compound that is not easily processible into a membrane, particularly a technique for fabricating a novel thin membrane of a composition that is gradually polymerized from a membrane surface into the membrane in the cross sectional direction of the membrane, and having, for example, different structures on the front and back of the membrane. The technique includes the steps of preparing a solution of a starting material compound; forming a thin membrane of the solution on a base material surface; and forming the organic polymer thin membrane through a polymerization reaction caused by irradiating the exposed surface of the thin membrane with a plasma or an electron beam.

Organic polymer thin membrane, and method for producing same

Provided is an observation method by an electron microscope, in which a biological sample can be observed as it is alive and a situation that the biological sample is moving can be observed using an electron microscope, and a composition for evaporation suppression under vacuum, a scanning electron microscope, and a transmission electron microscope used in the method. The sample observation method by an electron microscope according to the invention includes applying a composition for evaporation suppression containing at least one kind selected from an amphiphilic compound, oils and fats, and an ionic liquid to the surface of a sample to form a thin film, and covering the sample with the thin film, and displaying an electron microscopic image of the sample, which is covered with the thin film and accommodated in a sample chamber under vacuum, on a display device.

Electron microscopic observation method for observing biological sample in shape as it is, and composition for evaporation suppression under vacuum, scanning electron microscope, and transmission electron microscope used in the method

The present invention provides a tissue construct-forming substrate for forming a three-dimensional tissue construct containing proliferating cells, the substrate including a porous film having through-holes, and the porous film having, on the surface of the film, a cell adhesive region capable of retaining cells and a cell non-adhesive region located at a peripheral region of the cell adhesive region, a tissue construct-forming kit comprising the above-mentioned tissue construct-forming substrate and a frame, and a method for forming the above-mentioned tissue construct.

Substrate for forming a three-dimensional tissue construct and method of use

A slide member includes a substrate that is made of a metal material and has a sliding surface with a plurality of microdimples formed therein. Each of the microdimple has a circular opening, the microdimples are arranged in regular intervals in a hexagonal close-packed configuration, and the area ratio of the openings of all the microdimples to the entire sliding surface is in the range of 50 to 80%.

Slide member and method for the production thereof

The invention relates to a honeycomb film made of a biodegradable polymer which has biodegradation properties as an anti-adhesion membrane for preventing adhesion after an operation, is excellent in handling properties, and exhibits a satisfactory adhesion preventive effect stably over a desired period of time, and to a production process of the same. Above all, the invention provides an anti-adhesion membrane of a honeycomb film made of polylactic acid as a biodegradable polymer and a phospholipid and a production process of the same.

Biodegradable film having honeycomb structure

A tissue regeneration substrate comprising a film with a honeycomb structure composed primarily of a polymer compound and a phospholipid. A tissue regeneration complex comprising the tissue regeneration substrate and cells held in the tissue regeneration substrate. The substrate is particularly suitable for regeneration of cartilage tissue, and allows growth of cartilage tissue in a three-dimensional fashion.

Tissue regeneration substrate, complex thereof with cells, and method for its production

A solution having a polymer dissolved in a hydrophobic organic solvent is cast on a substrate, said organic solvent is evaporated in a moist atmosphere to condense moisture contained in an atmosphere prevailing on a surface of said cast solution into micro-droplets, said micro-droplets are dispersed on the surface of said cast solution or in said cast solution into a close-packed structure, said micro-droplets, condensed and dispersed on the surface of said cast solution or in said cast solution, are evaporated to obtain a porous honeycomb structure with said droplets used as casts, and said porous honeycomb structure is at least bisected by peeling in a thickness direction, thereby obtaining honeycomb structures wherein micro-pillars or anisotropic micro-pillars are regularly formed and arranged by said bisection on the peeled sections.

Process for producing micropillar structure

This invention provides a nanodisk, which can be formed of a wide variety of materials and has a high level of application, and a method for manufacturing the same. The nanodisk comprises fundamental units formed of two-molecule block copolymers arranged in series in a main chain direction, the fundamental units having been aggregated in a plane direction. The nanodisk has a thickness of 1 nm to 100 nm, a diameter of 10 nm to 5 &#x3bc;m, and an aspect ratio of not less than 1. Since the thickness of the nanodisk is not more than 100 nm, the nanodisk is transparent to light in a visible region. Further, when a metal element is held on the crosslinked structure part, the nanodisk can be utilized as a nanodisk having magnetic properties and electroconductive properties, or a nanodisk having catalytic activity and a high refractive index. Thus, the nanodisk can be applied to a wide variety of fields such as fine particle/powder technology, colloid surface science, electronic materials, and optical materials.

Nanodisk comprising block copolymer

A process for the production of a honeycomb-like porous body of 10 to 1000 nm in thickness which is made of a water-insoluble polymer and has pores having diameters of 10 to 100 nm, which comprises the following steps: (1) the step of dissolving a water-insoluble polymer in a water-incompatible organic solvent having a surface tension (&#x3b3;L) of 50 dyne/cm or below to prepare a solution of the polymer in the organic solvent, (2) the step of applying the solution prepared in the step (1) to the surface of a substrate with the proviso that the surface tension (&#x3b3;S) of the substrate, the surface tension (&#x3b3;L) of the organic solvent, and the surface tension (&#x3b3;SL) between the substrate and the solvent satisfy the relationship: &#x3b3;S&#x2212;&#x3b3;SL&#x3e;&#x3b3;L, and (3) the step of bringing the solution applied on the substrate into contact with air having a relative humidity of 30% or above to evaporate the organic solvent at such a rate that the coating thickness at applying the solution to the surface of the substrate is reduced to one-fifth within one second.

Process for production of submicrohoneycomb structures

A composite metallic materialaccording to the invention is used for, e.g., electrolytic capacitors, and includes a metallic material substrateand a high polymer thin layerhaving a fine patternformed on at least one surface of the substrateby self-organization. This high polymer thin filmis formed by, for example, drying hydrophobic organic solvent solution of high polymer compound. By subjecting this composite metallic materialto etching processing, etching pits are formed uniformly with high density based on the fine pattern.

Composite metal material and method for manufacturing the same, etched metal material and method for manufacturing the same and electrolytic capacitor

The present invention has an object to provide an easy method for detecting a nucleic acid polymer in aqueous phase. The present invention provides a method for detecting the amount of nucleic acid polymer, which comprises the steps of modifying an intercalator to be amphiphilic by using a hydrophobic group, spreading the amphiphilic intercalator on an aqueous solution containing a nucleic acid polymer to form a monolayer of said nucleic acid polymer and said amphiphilic intercalator at the gas-water interface, and measuring surface pressures per unit area of said monolayer.

Nucleic acid polymer/intercalator monolayer and methods of using and

Method for detecting nucleic acid polymer

Growing community of inventors

Hokkaido, Japan

Masatsugu Shimomura