Terumo Kabushiki Kaisha

Terumo Bct, Inc.

Masatsugu Igarashi

James R Ladtkow

Takemi Kobayashi

Andrew Gloor

Jesse Janzen

David Benz

Davis Benz

Debis Benz

A biological component treatment system is equipped with a biological component kit having a path through which a culture medium is capable of flowing, and a biological component treatment device that controls a flowing state of the culture medium. A method for culturing cells includes performing a measurement of information in relation to lactic acid, calculating a number of cells during culturing of cells on the basis of the obtained information in relation to lactic acid and calibration information, and controlling supply of the culture medium to the cells on the basis of the number of cells.

Biological component treatment system, biological component treatment device, and cell culturing method

A sampling method includes a sampling step and a cleaning step. The sampling step includes a first sample introduction step of introducing a first sample from a first cell culturing device to a more downstream side than a first connection portion in a sampling flow path, a first returning step of causing the first sample in the sampling flow path to flow into an introduction path from the first connection portion after the first sample introduction step, and a first flowing step of bringing the first sample into contact with a second sensor after the first returning step.

Sampling method

A flow path sealing structure according to at least one embodiment of the present disclosure, which is disposed on a way of a flow path formed by fusion bonding a pair of resin sheets that are superimposed on each other, includes a widened portion surrounded by a widened seal portion formed by fusion bonding together the pair of resin sheets around a periphery thereof, and one end and another end of which are in communication with the flow path, together with being formed to be wider than the flow path, and a weakly sealed portion formed to extend in a widthwise direction in the widened portion, and which partitions the widened portion in a liquid-tight and airtight manner into the one end and the other end, together with being capable of being opened by increasing an internal pressure of the widened portion.

Flow path sealing structure, bag-shaped container, and method of manufacturing the same

A flow path device of a biological component bag system is equipped with a device main body. The device main body includes a first sheet and a second sheet, and flow paths are formed between the first sheet and the second sheet. The flow paths include a first flow path, a second flow path, a filter accommodating chamber, and a third flow path. In the device main body, flow path sealed portions that join the first sheet and the second sheet to each other in a liquid-tight manner are disposed along the flow paths.

Flow path device and biological component bag system

A biological component separation device includes a device main body which is formed of a soft material in a sheet-like shape and in which a filter accommodating unit is provided, a filter member, an introduction port member, and a lead-out port member. An introduction line and a lead-out line are provided in the device main body. In a state in which the device main body is suspended by an introduction tube, a filter accommodating unit inlet where the filter accommodating unit and the introduction line are connected is positioned lower than a filter accommodating unit outlet where the filter accommodating unit and the lead-out line are connected.

Biological component separation device

A multi-tubing pinch valve assembly including a receiving space defined between a pinch protrusion and tubing contact body. The multi-tubing pinch valve assembly is moveable between a retracted state and an extended state. In the extended state, multiple tubes disposed in the receiving space are pinched, restricting flow therethrough. In the retracted state, multiple tubes are capable of being loaded into and/or out of the receiving space.

Multiple-tube pinch valve assembly

Provided is a blood component collection cassette capable of measuring a circuit internal pressure using a simple and economical configuration. A blood component collection cassette includes an inflow line for sending blood or a blood component collected from a donor to a centrifugal separator, a return line for returning a predetermined blood component to the donor, and a line forming member forming one of the inflow line and the return line and having a load detection soft portion made of a soft material.

Blood component collection cassette having flow control features for pressure sensing

In a blood transfusion system (a blood transfusion kit, a blood transfusion kit for emergency blood transfusion, or a method of using a blood transfusion kit), a flow path through which blood flows is formed using a tube having a channel therein. The flow path includes: a first path that connects an upstream path and a downstream path and has a leukocyte removal filter removing leukocytes at an intermediate position of the channel and a second path that connects the upstream path and the downstream path and bypasses the leukocyte removal filter.

Biological component collection device with internal pressure sensor and method

A blood component collection cassette that can trap a foreign object such as a blood-coagulated clot from blood components to be returned to a blood donor and a manufacturing method of the blood component collection cassette are provided. A sheet-shaped filter member () is arranged on a flow path () in a cassette main body () of a blood component collection cassette (). A first tube () and a second tube () are arranged in the cassette main body (). An inner space () of a filter housing unit () is separated by the filter member () into a first space () on the side of the first tube () and a second space () on the side of the second tube ().

Blood component collection cassette and manufacturing method of the same

A blood component collection cassette has a flow path in the interior thereof through which blood flows, and a cassette main body composed of a resin that possesses flexibility. The cassette main body includes a first constituent part in which a plurality of concavities and convexities are formed. Furthermore, a resin sheet includes a second constituent part, which is provided on one portion of an outer surface of the flow path wall portion that constitutes the flow path, and in which the plurality of concavities and convexities do not exist.

Biological component collection cassette, kit, or system, and method of manufacture

A flow path is formed in a cassette body of a blood component collection cassette. The cassette body includes a bulging structure in which at least a portion of the flow path is formed. A first gripped member, which is configured to be gripped by a first gripping member provided on a centrifugal separation device, is disposed on one surface of the bulging structure in a thickness direction thereof. A second gripped member, which is configured to be gripped by a second gripping member to which a load detection unit that is provided on the centrifugal separation device is fixed, is disposed on another surface of the bulging structure in the thickness direction thereof.

Blood component collection bag set with internal pressure detection and method

A blood component collection cassette of a blood component collection system, which is a biological component transfer system, includes a sheet-shaped cassette main body in which a blood line is formed. The blood line includes a second applied load measurement unit and line main body portions. A separation device includes a second load measurement unit that measures a load applied to a wall portion of the second applied load measurement unit in a cassette mounted state. The second applied load measurement unit is more easily deformed than the line main body portions, and is disposed at a location within the blood line on which only a positive pressure acts.

Blood component separation apparatus with internal pressure monitor

A blood component sampling cassette which can be more efficiently manufactured at lower cost as compared to a typical cassette, a blood sampling circuit set, and a blood component sampling system. A blood component sampling cassette () includes a cassette main body () made of a soft material to which heat sterilization is applicable. The cassette main body () is provided with a retransfusion line (). The retransfusion line () is provided with a reservoir () configured to temporarily store a blood component to be returned to a blood donor. The reservoir () is pressed by a retransfusion pump () to discharge the blood component from the reservoir ().

Blood component sampling cassette, blood sampling circuit set, and blood component sampling system

Provided are a blood bag system and a blood treatment method capable of securely and efficiently obtaining a medium specific gravity blood component having a sufficiently low content rate of a light specific gravity blood component. In a blood bag system () used for a blood treatment method, in a transfer completed state in which whole blood in a first bag () is centrifuged to transfer blood plasma to a second bag () through a first transfer tube () and transfer red cell concentrates to a third bag () through a second transfer tube (), a buffy coat is left in the first bag (). In the transfer completed state, when a platelet added solution is transferred from a fourth bag () to the first bag () on which a centrifugal force acts through a third transfer tube (), blood plasma in the buffy coat is discharged from the first bag ().

Blood bag system and blood treatment method

Provided is a blood component sampling cassette which can be efficiently manufactured at low cost compared to a conventional cassette, a method for manufacturing the blood component sampling cassette, a blood sampling circuit set and a blood component sampling system. The blood component sampling cassette includes a cassette main body having a plurality of flow paths including an introduction line, a blood component transfer line and a retransfusion line. The cassette main body includes a first sheet and a second sheet which are formed of a soft material compatible with autoclave sterilization. The first sheet and the second sheet are overlaid in a thickness direction and bonded to each other. A plurality of flow paths is formed between the first sheet and the second sheet.

Blood component sampling cassette, method for manufacturing blood component sampling cassette, blood component sampling circuit set, and blood component sampling system

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Shizuoka, Japan

Masatsugu Igarashi